NF-κB and Cancer 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 148
Special Issue Editor
Interests: development of phytochemicals for cancer prevention and therapeutics; targeting STAT-3, NF-kB, HER2, MCL-1, AKT/FOXO, GLI1/2, and related signaling pathways with agents such as capsaicin, piperlongumine, penfluridol, isothiocyanates, diindolylmethane, panabinostat, cucurbitacin B, and deguelin in pancreatic, ovarian, breast, melanoma, and brain cancer; drug repurposing
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Special Issue Information
Dear Colleagues,
The nuclear factor κB (NF-κB) belongs to a family of transcription factors that are involved in the orchestration of different biological processes. It plays a recognized role in the regulation of immune response and inflammation. However, several studies have shown aberrant activation of NF-κB in various solid tumors. Activation of NF-κB may result from different signalling pathways triggered by a variety of growth factors, cytokines and tyrosine kinases. Several cell survival genes regulated by NF-κB play a critical role in the development and progression of cancer. Taken together, all studies establish NF-κB as an important therapeutic target for the treatment of cancer. This Special Issue on “NF-κB and Cancer” addresses the biology of NF-κB in cancer and its inhibition by various natural products and synthetic agents, leading to tumor growth suppression and clinical development of inhibitors.
Prof. Dr. Sanjay K. Srivastava
Guest Editor
Manuscript Submission Information
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Keywords
- NF-κB
- inflammation
- cell signaling
- animal models
- immune check points
- natural products
- phytochemicals
- small molecule inhibitors
- apoptosis
- proliferation
