Ways to Model Neurologic Disorders: New Insights

Dear Colleagues,

Animal models play a fundamental role for understanding the pathogenesis of several human disorders, but not all diseases can be reproduced in animals. For this reason, the development of the induced pluripotent stem cell (iPSC) technology has become relevant for modelling human disorders. Since 2007, many diseases have been modelled by using iPSCs and, most recently, organoids, i.e., three-dimensional multicellular structures arising from iPSCs, which offer the unique opportunity to investigate and understand the complex 3D cellular phenotype of numerous human pathologies. Modelling human disorders is important as it both improves our comprehension of disease pathogenesis and offers the opportunity to test mechanistically constructed therapeutics which may effectively treat and/or prevent neurological disorders.

This Special Issue will focus on recent advances in the generation of human disease models, with particular emphasis on models of neurologic disorders. Articles offering innovative insights into the multifaceted pathophysiology of neurological diseases are welcome. Original research articles and reviews are invited on all aspects of neurological disease modelling, from animal models to models based on human iPSCs and 3D organoids that better represent the in vivo environment.

 

Dr. Claudia Compagnucci
Dr. Emanuela Piermarini
Guest Editors

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