State-of-the-Art Molecular Oncology in Chile

Dear Colleagues,

The aim of this Special Issue is to present the latest advances in cancer research in Chile from the point of view of different research studies in molecular oncology.

With the situation of the SARS-CoV-2 (COVID-19) pandemic, cancer patients have delayed their diagnoses and treatments; as such, the main cause of death in the near future will be cancer, not only in Chile but also in many other countries.

The assessment of basic and clinical studies of different types of cancer is fundamental to the search for better biomarkers that can be applied in the prevention and early detection of cancer. Moreover, the finding of genetic markers will allow typing and/or classifying tumors in target tissues from a therapeutic point of view. In addition, it is relevant to gain knowledge on the participation of different oncoproteins in cancer progression. Therefore, the search for new therapies complementary to the current ones is of great importance, since cancers eventually end up becoming resistant to those therapies in most cases.

Additionally, molecular biology has been a fundamental tool to successfully overcome these challenges and achieve the proposed objectives. In fact, in recent years, a relevant course of study involves finding new molecules, such as oncoproteins and noncoding RNAs, that are both involved in cancer progression and can be utilized in potential adjuvant therapies.

In this regard, there is currently great interest in the importance of exosomes in some processes of cancer, such as metastasis, and the role of exosomes with specific cargo that may potentially be used in therapy. In addition, the development of nanoparticle systems with different molecules as cargo for use in possible new therapies will be of importance.

The aim of this Special Issue is to provide a comprehensive view of recent advances in cancer research in Chile. We invite you to submit research and review papers that will consolidate our understanding in this area. Potential topics include but are not limited to the following:

1. Process involved in EMT in different type of cancer
2. Oncoproteins involved in different process in cancer
3. Role of exosomes in cancer    
4. Role of noncoding RNAs in cancer
5. Use of nanosystems as adjuvant or complementary therapies in cancer
6. Use of bioinformatics in cancer with a strong emphasis on molecular biology and molecular medicine
7. Tumoral microenvironment
8. Carcinogenesis in prevalent cancers in the Chilean population

Prof. Dr. Juan Carlos Roa
Prof. Dr. Carmen Aurora Romero
Dr. Hector R. Contreras
Guest Editors

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