Central and Peripheral Molecular Mechanisms of Metabolism Regulation

Dear Colleagues,

Control of the peripheral organ metabolism and the whole-body energy homeostasis are realized through a tight integration among hormonal, dietary, and  nervous physiological mechanisms. Topics of special interest are the mechanisms by which  dietary nutrients and drugs, acting on peripheral targets directly or indirectly at various levels of the microbiota–gut–brain axis,  affect metabolism and  inflammatory processes which, in turn, influence eating behavior and impact the course of many diseases; similarly interesting are the molecular mechanisms linking cell metabolism and growth for the understanding of metabolic alteration in cancer cells.  Despite growing progress in this area, many questions remain unresolved, with particular regard to the mechanisms of metabolism control at a molecular level. Indeed, a better understanding of how the metabolism is dysregulated in disease state can lead to the potential development of new drugs targeting metabolic pathways.  To contribute to a greater knowledge in this field, the aim of this Special Issue is to collect original papers and reviews dealing with central and peripheral molecular mechanisms underlying metabolism regulation and their disruption in diseases with significant metabolic implications, including cardiovascular diseases, obesity, neurodegenerative diseases, and cancer. Papers addressing dietary and hormone molecular mechanisms of control of adipose tissue, muscle, bone or liver metabolism  as well as central molecular mechanisms of metabolism control and energy balance are welcome.

Prof. Dr. Mariarosaria Santillo
Dr. Simona Damiano
Guest Editors

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