Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration - Part II

Dear Colleagues,

The first Special Issue “Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration” has been recognized by many scientific groups and was a successful endeavor. This encouraged us to continue this Special Issue with a second part devoted to research concerning mesenchymal stem cell application in regenerative medicine.

Mesenchymal stem/progenitor cells (MSCs) reside in many human tissues and organs and play important roles in tissue regeneration and tissue homeostasis. These cells can be isolated from different tissues in the adult human body, expanded in vitro and applied for the regeneration of tissues and organs damaged by age, disease or extensive injury. Cells bearing MSC characteristics differ in the facets of proliferation and differentiation, which results in their diverse biological potential and applications in tissue regeneration. Experimental studies have shown that not only MSCs, but also their derivates—such as a conditioned medium containing a variety of bioactive factors or extracellular vesicles (EVs) (microvesicles and exosomes) carrying various cytoplasmic components, including lipids, DNA fragments and RNA (including mRNA and microRNA)—contribute to tissue recovery and angiogenesis and modify the inflammatory microenvironment in a paracrine and endocrine manner. This Special Issue will present state-of-the-art studies concerning the therapeutic effects of various stem/progenitor cells and/or their derivates in the context of tissue and organ regeneration. The potential topics to be covered include (1) bioactive factors released by mesenchymal stem/progenitor cells for cell-free therapy in tissue regeneration, (2) extracellular vesicles from parental mesenchymal stem/progenitor cells for cell-free therapy in tissue regeneration and (3) the proangiogenic properties of bioactive factors and/or extracellular vesicles released by MSCs.

Prof. Dr. Aleksandra Klimczak
Guest Editor

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