Genome Instability in Health and Disease

Dear Colleagues,

A stable genome is a fundamental characteristic of all eukaryotes that is essential for the maintenance and accurate segregation of genetic material in daughter cells. As such, genome stability is vital for normal cell function, physiology, and ultimately species survival. Despite its critical nature, the extensive array of genes, proteins and cellular processes required for genome stability remain poorly understood. Nevertheless, there exist many well characterized processes that are essential for preserving genome stability including DNA repair, DNA replication, centrosome biology, chromatin compaction and chromosome dynamics. Consequently, the aberrant expression, function and regulation of these processes is implicated in disease pathogenesis but is also being explored as a potential therapeutic strategy for disease like cancer.

This Special issue aims to expand our current understanding of genome stability in both physiological and pathological conditions, and on its possible therapeutic exploitation. Experimental studies employing in vitro and in vivo models or review articles are welcome for consideration. As IJMS is a molecular sciences journal, clinical studies will not be considered; however, clinical submissions with biomolecular experiments are welcomed.

Dr. Kirk McManus
Guest Editor

Manuscript Submission Information

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