Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

Dear Colleagues,

The objective of this Special Issue is to improve our knowledge regarding the cellular and molecular mechanisms involved in autophagy and oxidative stress. Oxidative stress and redox signaling are largely involved in the etiology of human diseases, where both survival and cell death signaling cascades have been reported to be modulated by reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS activate autophagy, which facilitates cellular adaptation and diminishes oxidative damage by degrading and recycling intracellular damaged macromolecules and dysfunctional organelles; therefore, autophagy is a major cellular defense against oxidative stress, or related conditions that cause accumulation of damaged proteins or organelles.

This Special Issue, presided by Dr. Daniela Impellizzeri and Ramona D’Amico as Guest Editor, and Dr. Rosalba Siracusa as Topical Advisory Panel Member. We welcome research aimed at improving our understanding of molecular mechanisms and biomarkers through which oxidative stress and autophagy regulate human disease. Indeed, the identification of specific biomarkers of oxidative stress and autophagy is of great importance for disease prevention, monitoring disease progression and evaluating the effectiveness of treatments.

We welcome various types of manuscripts, including original research and review articles, clinical trials and instructive case reports.

Dr. Ramona D’Amico
Dr. Daniela Impellizzeri
Guest Editors

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