DNA and RNA Modifications in Epigenetic Regulation and Disease

Dear Colleagues,

The DNA and RNA of all living cells undergoes continuous structural chemical alterations occurring due to exposure to exogenous sources, or generated via endogenous metabolic pathways. Thus, it has been estimated that approximately 70,000 DNA lesions are generated every day in a single cell. Some of these modifications have been linked to a wide variety of diseases, including cancer.

Our current knowledge of the levels, genomic distribution and the degree of involvement of metabolic and environmental factors in the generation of RNA/DNA modifications is insufficient. Therefore, novel approaches for reliable identification, quantification and mapping the modifications in the genome and trascriptome can provide an insight into the mechanism of their action and biological relevance. Moreover, these techniques DNA may also be helpful as a clinical parameter for treatment monitoring, risk group identificationm and development of prevention strategies for a number of diseases.

This open access Special Issue will bring together original research and review articles on new findings, methods, and technical advances in molecular biology and functional consequences of nucleic acids modifications, including new methodological approaches and applications of established techniques.

The main feature of this Special Issue is to provide an open-source sharing of significant works that can increase our understanding of functional consequences of DNA and RNA modifications.

Dr. Daniel Gackowski
Dr. Alexey Ruzov
Guest Editors

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