Calcium Channels and Calcium-Binding Proteins

Dear Colleagues,

Signal of nerve impulses are transmitted to excitatory cells to induce action of organs via activation of Ca²⁺ entry through voltage-gated Ca²⁺ channels, which are classified based on their activation threshold into high- and low-voltage activated channels, expressed specifically for each organ. Ca²⁺ entered into excitatory cells binds to Ca²⁺-binding proteins which are classified into two groups of Ca²⁺ sensors, C2 domain and EF hand proteins. Within transient Ca²⁺ elevation, each Ca²⁺ sensor, having different affinity and binding speed to Ca²⁺, determines the timing of protein–protein interactions to produce the specific action of each organ. This Special Issue will focus on investigations ranging from the control of Ca²⁺ entry at the plasma membrane of excitatory cells to detailed studies of the intracellular mediation of Ca²⁺-binding proteins that catalyze the organ-specific action.

Prof. Dr. Sumiko Mochida
Guest Editor

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