Bioenergetics, Mitochondrial Dynamics and Cardiac Disease

Dear Colleagues,

Cardiovascular diseases remain the leading cause of death and disability worldwide despite the progress made over the past three decades in the prevention, diagnosis, and management of the disease. Thus, there is a substantial need to find novel approaches that could specifically address repair and regeneration of damaged and/or lost myocardium.

Cardiac disease is associated with metabolic changes that cause a progressive impairment of cardiac muscle high-energy phosphate production with further maladaptive effects. Advances in animal models and systems-based approaches have revealed that mitochondria have diverse functions beyond bioenergetics, and the ability to adapt and respond to a plethora of cellular and tissue-specific stimuli. Mitochondrial dysfunction has been identified as a key perturbation underlying numerous pathologies including heart failure and metabolic disorders. Emerging evidence highlights the connection between mitochondrial biology and changes in cardiac metabolism and their importance for cell survival and/or the progress of cardiac pathology.

This Special Issue will bring together reviews and original articles addressing the molecular signaling that connects metabolism and energy-sensing with mitochondrial function, and the roles of basic mitochondrial processes in metabolism and cardiac dysfunction. Identification of therapeutic targets and the development of novel approaches to treat cardiac diseases will be also a relevant aspect of this issue.

Prof. Antigone Lazou
Dr. Chrishan J.A. Ramachandra
Guest Editors

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