Special Issue "Molecular and Cellular Signaling on Antidepressant Mechanisms"
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 13242
Interests: neuropharmacology; neuropsychopharmacology; opioid; anxiety; depression; reward; fear; antidepressant; anxiolytics; animal model
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Hypotheses on the pathophysiology of depression and mechanisms of antidepressants have greatly changed in recent years. For example, although the classical monoamine hypothesis was revealed to be simplistic, it failed to explain the temporal delay in the therapeutic action of antidepressants. Hence, there remains a clear need to understand the factors associated with the mechanisms underlying antidepressant effects for developing effective, reliable, and safe treatments that have fast action and bring sustained benefits for patients. Recently, several unique mechanisms of neuroplasticity were analyzed in studies of the mechanisms of antidepressants; these range from changes in gene and molecular expression to synaptic plasticity and transmission. Converging lines of evidence have shown that adaptive changes in several of these mechanisms of neuroplasticity are likely to represent the molecular and cellular signaling correlated to therapeutic effects.
The present Special Issue aims to provide an overview of the current research on the promising molecular and cellular signal hypotheses of mechanisms of antidepressants for both standard psychotropic drugs and candidate therapeutic agents for depression that look beyond non-monoaminergic mechanisms.
Prof. Dr. Akiyoshi Saitoh
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