Calcium Channel Signaling: From Molecular Structure to Physiological Function

Dear Colleagues,

Calcium ions (Ca²⁺) function as ubiquitous intracellular messengers that regulate a broad spectrum of cellular activities, including muscle contraction, neurotransmission, gene expression, and cell proliferation. The precise control of intracellular calcium levels is primarily mediated by a diverse array of calcium-permeable channels, such as voltage-gated calcium channels (VGCCs), store-operated calcium entry (SOCE) systems, and transient receptor potential (TRP) channels.

Recent advances in structural biology and imaging technologies have significantly enhanced our understanding of the molecular architecture and gating mechanisms of these channels. At the same time, growing evidence underscores the importance of spatiotemporal calcium signaling in coordinating complex physiological functions. Dysregulation of calcium channels has been implicated in numerous pathological conditions, including cardiovascular diseases, neurodegenerative disorders, and cancer.

This Special Issue, “Calcium Channel Signaling: From Molecular Structure to Physiological Function”, aims to present recent developments in the field by bringing together studies that explore calcium channel structure, regulation, and function across different biological levels. Contributions addressing both fundamental mechanisms and translational aspects are highly encouraged to foster a comprehensive understanding of calcium signaling and its therapeutic potential.

Dr. Dongki Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.