Biological Effects of Low-Dose and Low-Dose-Rate Ionizing Radiation Exposure 2.0

Dear Colleagues,

Evaluation of the health risks associated with exposures of humans to low-dose and low-dose-rate ionizing radiation is prone to uncertainties due to the lack of knowledge of molecular mechanisms that underlie long-term health effects. This Special Issue will highlight the latest research on cellular and molecular effects of low-dose and low-dose-rate ionizing radiation exposures, such as DNA damage and repair, signal transduction, translation regulation, epigenetic rearrangement, and how they convert to cancer and non-cancer disease. We therefore invite research articles presenting novel results, reviews, and/or perspectives addressing or systematizing pertaining knowledge in this area. The specific topics that can be covered include but are not limited to:

• Links between initial DNA damage and subsequent mutagenesis and carcinogenesis;
• Mechanisms of radioadaptive responses and hormetic effects;
• The effect of dose rate on a choice of a DNA damage response pathway;
• Molecular biomarkers of exposure and bioindicators of health risks;
• Molecular responses to internal vs. external irradiation; radionuclide-specific effects;
• Effects of chronic cosmic radiation exposures associated with long-term manned space missions;
• Advances in molecular epidemiology;
• Application of artificial intelligence/machine learning to decoding low-dose and low-dose-rate molecular mechanisms;
• Consolidation of the knowledge of molecular mechanisms within the concept of adverse outcome pathways.

We look forward to your valuable contributions.

Prof. Dr. Andreyan N. Osipov
Dr. Dmitry Klokov
Guest Editors

Manuscript Submission Information

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• ionizing radiation
• low dose
• low dose rate
• DNA damage and repair
• molecular mechanisms
• cellular radiation effects
• radioadaptive response
• radiation hormesis
• bystander effect
• biomarkers
• molecular epidemiology
• carcinogenesis
• radioprotection