Molecular Advances on Insulin Resistance and Metabolic Dysfunction, 2nd Edition

Dear Colleagues, 

Worldwide, the obesity epidemic has resulted in a surge of metabolic abnormalities and diseases stemming from the condition of insulin resistance that accompanies the obesity status. Insulin resistance represents an impaired biological response to insulin stimulation of target tissues, primarily liver, muscle, and adipose tissue. It is recognized as the root for hypertension, dyslipidemia, non alcholic fatty liver disease, policistic ovary syndome, atherosclerosis, and adverse cardiac remodeling/heart failure. Alterations in glucose and lipid metabolism, insulin secretion and action are among the most important mechanisms that explain the onset of these diseases.

Several modifiable and non-modifiable factors are implicated. Among modifiable risk factors sedentarity and unhealthy diets rich in saturated fat are the most important. However, it is becoming clear that during the last century the production and release of chemicals in the environment has increased and this per se has an effect on health. These chemicals once inhaled or ingested (since they are present in water and in the food chain) may act as endocrine disruptors (EDC) thus increasing the development of metabolic diseases and related comorbidities.

We invite investigators to contribute either original research articles or review articles focusing on the variety of molecular mechanisms that either contribute to the worsening of insulin resistance in obese patients, or that, triggered by insulin resistance, cause the onset and progression of comorbidities associated with obesity.

Prof. Dr. Melania Manco
Prof. Dr. Amalia Gastaldelli
Guest Editors

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