Steroidal Anticancer Agents for Treating Gynecological Cancer

Dear Colleagues,

Nearly 60 years ago the first scientific article about cancer cell proliferation inhibiting effect of cardiac glycosides was published. Since then the scientific interest has not declined in connection with novel anticancer agents with widely modifiable sterane skeleton. Thanks to the permanent and intensive research work in this field, numerous steroidal anticancer agents (e.g., fulvestrant, estramustin, cyproterone and exemestane) have become significant members of antitumor protocols. In addition, substantially diverse anticancer mechanisms of action have been described such as steroidal receptor antagonism, enzyme inhibition and surprising direct antiproliferative activity as well as promising inhibitory effect on multi-drug resistance. Therefore, these molecules still deserve outstanding attention in the field of anticancer research.

This Special Issue of the International Journal of Molecular Sciences entitled “Steroidal Anticancer Agents for Treating Gynecological Cancer”, will focus on recent advances in newly synthesized compounds with sterane skeleton and their anticancer effect, such as structure-activity relationships, molecular mechanism of antitumor and antimetastatic effect, mechanisms of multi-drug resistance reversal features and investigation of the structural background of the anticancer activitiy at atomic level using computational simulation. Contributions on these related topics are welcomed, including original research and full reviews. We also very much welcome tasks of postdocs, PhD students, and young researchers.

Dr. Renáta Minorics
Dr. Erzsébet Mernyák
Guest Editors

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