Application of Genomics in Complex Disorders: Focus on Pharmacogenomics Informed Theraputics

Dear Colleagues,

The field of genomics has seen unprecedented progresses in the development of novel experimental and analytical tools that are supporting the transition of clinical practice toward precision medicine. Data driven medical approaches are starting to see implementation in several areas including oncology, neurology, and to some extent, psychiatry. The use of omics technologies, integrated by digital monitoring data, electronic health records, and other omics technologies (metabolomics, proteomics, epigenomics) is increasing the accuracy of prediction for specific for complex traits. For instance, the analysis of genome-wide derived polygenic risk score integrated by cognitive data and brain imaging has reached adequate levels of accuracy for clinical implementation in neurodegenerative disorders. This special issue aims to collect novel research data and syntheses of the literature on the progresses of genomic research in complex disorders, focusing on the clinical relevance of risk prediction algorithms and data driven clinical decision making (i.e., pharmacogenomics informed theraputics).

Prof. Dr. Mirko Manchia
Guest Editor

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