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Special Issue "Metabolomics Approach to Tackle Toxicological and Pharmacological Issues"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 20 July 2023 | Viewed by 180

Special Issue Editors

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal
Interests: mechanisms of toxicity; genotoxicity; DNA damage; oxidative stress inducers; antioxidants; SOD mimics; chemotherapeutic drugs; DNA repair inhibitors; cytotoxicity
UCIBIO-REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: toxicology; GC-MS; biomarker discovery; toxicometabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The identification and quantification of metabolites responding to a specific stimulus is of the utmost importance in tackling toxicological and pharmacological issues. In fact, in the field of metabolomics, information concerning the pattern of the low-molecular-weight compounds generated in a biological system upon exposure to xenobiotics provides new insights into the cellular and organ-specific pathways involved.

Metabolomics thus represents a powerful tool to evaluate the mode of action of drugs and chemical contaminants. Moreover, toxicometabolomics and pharmacometabolomics data may clarify the differences observed in drug responses (i.e., responders vs. non-responders) and help identify biomarkers related to drug efficacy or toxicity. These approaches are also critical to providing pharmacokinetics (PK) and pharmacodynamics (PD) data for use in precision medicine.

In view of this, we are inviting you to submit your experimental work or a review article on a pertinent subject within the scope of this Special Issue. This is an excellent opportunity for researchers from different fields of expertise to disseminate their recent findings and keep themselves up to date on this emerging topic.

Dr. Nuno G. Oliveira
Prof. Dr. Paula Guedes De Pinho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metabolomics
  • metabolites
  • drugs
  • contaminants
  • xenobiotics
  • toxicity
  • pharmacology
  • toxicology

Published Papers

This special issue is now open for submission.
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