Zebrafish Model for Toxicological and Pharmacological Research

Dear Colleagues,

The zebrafish (Danio rerio) has long been used as a model species for developmental biology studies. Zebrafish, however, offer considerably more as a model species and are now involved in many different research fields including, toxicology, neurobiology, immunology, and cancer, just to name a few. In addition, the employment of zebrafish embryos has enormously facilitated different sort of chemical testing, from pollutants toxicity assay to high-throughput drug screening. The relevant genetic homology with humans, the applicability of genome editing and transgenesis technologies, together with easy and low-cost protocols to expose the embryos to different compounds, make zebrafish a powerful tool for modeling human diseases and better understanding cellular and molecular mechanisms of toxicants and new therapeutics. Indeed, the potential of zebrafish is becoming increasingly evident, and the availability of these models allows for an increased understanding of the role of chemical exposure in human disease. In this Special Issue, we welcome contributions that show recent developments in zebrafish as a model for toxicological research and drug discovery, as well as new insights on the effects of chemical exposure in zebrafish models of human diseases. Translational studies that employ molecular methods to enhance our understanding of human health or environmental risk are also of interest.

Dr. Luca Del Giacco
Guest Editor

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