Microbial Fermentation Optimization and Product Bioactivity

Dear Colleagues,

This Special Issue in the International Journal of Molecular Sciences focuses on fermentation and bioreactors in biosciences, aiming to highlight recent advances, emerging technologies, and interdisciplinary research. The Issue will emphasize key areas including the molecular mechanisms underlying microbial fermentation (e.g., metabolic regulation, signaling pathways, and gene expression control), molecular biology approaches for strain engineering (e.g., CRISPR-based genome editing, synthetic biology tools, and adaptive laboratory evolution), the molecular mechanisms of action underlying the bioactivity of fermentation-derived products (e.g., polysaccharides, peptides,  secondary metabolites, and novel bioactive compounds), and molecular-level process optimization (e.g., systems biology, metabolic flux analysis, and AI-driven bioprocess control).

Additional highlights include multi-omics integration (genomics, transcriptomics, proteomics, and metabolomics) for fermentation analysis, microbiome engineering and microbial consortia design, bioreactor design and scale-up strategies informed by molecular data, stress tolerance mechanisms in industrial microorganisms, sustainable and green bioprocessing approaches, discovery of novel bioactive compounds, precision fermentation for high-value products, and data-driven modeling and digital twins for fermentation systems.

Dr. Wai Prathumpai
Guest Editor

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