Recent Advances in Breast Cancer Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 37499
Special Issue Editor
2. Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University Magdeburg, Pfälzerplatz 2, 39106 Magdeburg, Germany
Interests: breast cancer; thyroid cancer; prostate cancer; cell biology; gravitational biology; space medicine; tissue engineering; pharmacology; apoptosis; SOX transcription factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically in recent decades. Dismissed as an “unsolved problem of the last century”, breast cancer still represents a health burden with no effective solution identified so far. As estimated by the latest GLOBOCAN (Global Cancer Observatory) survey in 2020, breast cancer (BC) comprises 2.3 million new cases of female BC and 684,996 death incidents worldwide. Local options for treatment are surgery and radiation. Systemic treatments comprise chemotherapy, hormone therapy, immunotherapy, and drug-targeted treatment strategies. Various drugs are available for BC therapy, but adverse effects and the problematic development of drug resistance make it important to search for novel strategies and new drug targets. This SI will provide an updated overview covering all aspects of targeted therapies in breast cancer, from basic science to the clinical trials. In addition, there will be a special focus on potential biomarkers that are predictive for a therapeutic response.
Furthermore, new research fields comprise organoid studies and microgravity (µg) research, which is an unusual method to combat the disease. Numerous studies have indicated that µg has a great impact on cancer cells. By influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less-aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and for the study various processes of cancer progression.
In this SI, studies using animal or cell culture models to investigate molecular mechanisms of BC will be published. This SI will also cover reports on patients, providing novel mechanistic insights into the underlying pathogenesis or new aspects that may impact clinical therapy.
Dr. Daniela Grimm
Guest Editor
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Keywords
- breast cancer
- drugs
- OMICS investigations
- cell signaling
- biomarker
- tyrosine kinase inhibitors
- in vitro studies
- organoids
- animal studies
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