Advanced Extraction Technologies for Food Bioactive Compounds: Implications for Nutrition and Disease Prevention

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1541

Special Issue Editors


E-Mail Website
Guest Editor
Department of Food Science and Nutrition, University of Thessaly, Terma N. Temponera Street, 43100 Karditsa, Greece
Interests: extraction; green technologies; natural antioxidants; food waste valorization; food analysis; encapsulation; biological properties of natural extracts; food sustainability; circular economy

Special Issue Information

Dear Colleagues,

Advanced extraction technologies are reimagining the recovery of high‑value bioactive compounds from food matrices, enhancing yield, stability, and bioavailability while meeting the demand for greener, scalable solutions. This Special Issue stands out by linking cutting‑edge methods directly to mechanistic health benefits, personalized nutrition, and industrial application pathways.

Techniques, such as supercritical fluid extraction (SFE), ultrasound‑assisted extraction (UAE), microwave‑assisted extraction (MAE), enzymatic extraction, pulsed electric field (PEF)‑assisted extraction, pressurized liquid extraction (PLE), cold plasma pretreatment and the use of natural deep eutectic solvents (NADES), offer sustainable alternatives to traditional processes. Further examples include polyphenol‑rich extracts modulating inflammatory pathways, flavonoids supporting cardiovascular health, and carotenoids enhancing antioxidant defenses.

With the rise in personalized nutrition, tailored bioactive profiles are becoming central to disease prevention and public health. This Special Issue, entitled “Advanced Extraction Technologies for Food Bioactive Compounds: Implications for Nutrition and Disease Prevention”, welcomes original research, reviews, case studies, and technology notes from academia and industry worldwide, covering technological innovation, compound characterization, formulation strategies, and real-world applications.

Dr. Eleni Bozinou
Prof. Dr. Stavros I. Lalas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extraction techniques
  • bioactive compounds
  • natural antioxidants
  • biological properties
  • optimization
  • food waste valorization
  • food fortification
  • food sustainability
  • artificial intelligence in food industries
  • health promotion
  • natural products

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

29 pages, 3015 KB  
Article
Green Optimization of Sesame Seed Oil Extraction via Pulsed Electric Field and Ultrasound Bath: Yield, Antioxidant Activity, Oxidative Stability, and Functional Food Potential
by Vassilis Athanasiadis, Marianna Giannopoulou, Georgia Sarlami, Eleni Bozinou, Panagiotis Varagiannis and Stavros I. Lalas
Foods 2025, 14(21), 3653; https://doi.org/10.3390/foods14213653 - 26 Oct 2025
Viewed by 971
Abstract
Sesame seed oil is a bioactive-rich lipid source, notable for lignans, tocopherols, and unsaturated fatty acids that underpin its antioxidant and cardioprotective properties. This study optimized two innovative, non-thermal extraction techniques—pulsed electric field (PEF) and ultrasound bath-assisted extraction (UBAE)—to maximize yield and preserve [...] Read more.
Sesame seed oil is a bioactive-rich lipid source, notable for lignans, tocopherols, and unsaturated fatty acids that underpin its antioxidant and cardioprotective properties. This study optimized two innovative, non-thermal extraction techniques—pulsed electric field (PEF) and ultrasound bath-assisted extraction (UBAE)—to maximize yield and preserve oil quality for functional food applications. A blocked definitive screening design combined with response surface methodology modeled the effects of energy power (X1, 60–100%), liquid-to-solid ratio (X2, 10–20 mL/g), and extraction time (X3, 10–30 min) on fat content, DPPH antiradical activity, and oxidative stability indices (Conjugated Dienes, CDs/Conjugated Trienes, CTs). UBAE achieved the highest fat yield—59.0% at low energy (60%), high X2 (20 mL/g), and short X3 (10 min)—while PEF maximized DPPH to 36.0 μmol TEAC/kg oil at high energy (100%), moderate X2 (17 mL/g), and short X3 (10 min). CDs were minimized to 19.78 mmol/kg (UBAE, 60%, 10 mL/g, 10 min) and CTs to 3.34 mmol/kg (UBAE, 60%, 12 mL/g, 10 min). Partial least squares analysis identified X2 and X3 as the most influential variables (VIP > 0.8), with energy–time interplay (X1 × X3) being critical for antioxidant capacity. Compared to cold-pressing and Soxhlet extraction, PEF and cold-pressing retained higher antioxidant activity (~19 μmol TEAC/kg) and oxidative stability (TBARS ≤ 0.30 mmol MDAE/kg), while Soxhlet—though yielding 55.65% fat—showed the poorest quality profile (Totox value > 560). Both non-thermal techniques can deliver bioactive-rich sesame oil with lower oxidative degradation, supporting their application in functional foods aimed at improving dietary antioxidant intake and mitigating lipid oxidation burden. PEF at high energy/short time and UBAE at low energy/short time present complementary, scalable options for producing high-value edible oils aligned with human health priorities. As a limitation, we did not directly quantify lignans or tocopherols in this study, and future work will address their measurement and bioaccessibility. Full article
Show Figures

Figure 1

Back to TopTop