Nutraceuticals and Medicine Foods: Processing Technologies, Metabolic Mechanisms, and Human Health

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 685

Special Issue Editors


E-Mail Website
Guest Editor

E-Mail Website
Guest Editor
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
Interests: food chemistry; safety; food safety; food supplements and functional foods; nutraceuticals; sustainability; novel foods; nano-nutraceuticals; recovery from byproducts of the agri-food area; formulation and assessing of novel nutraceuticals; food contaminants; contaminants; risk assessment; mycotoxins and secondary metabolites; chemistry and food education
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA
Interests: food chemistry and processing; maillard reaction; flavor and sensory science; functional food; bioactive food; bioactive compounds from plants; structural characterization; Immunomodulatory activities; metabolism; antioxidants; metabolomics and analytical methods; chronic disease prevention

E-Mail Website
Guest Editor
Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA
Interests: food chemistry; phytochemistry; bioactivity-guided isolation of natural products; functional food; food bioactive compounds; 1D and 2D NMR elucidation; LC/MS analysis; essential oils; semi-synthesis of natural products; ethnopharmacology; microbial and fungal biotransformation

E-Mail Website
Guest Editor
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
Interests: cardiovascular disease; diabetes; obesity; human metabolism; epigenetics; nutritional biochemistry; cellular and molecular biology; enzymology; chronic disease

E-Mail Website
Guest Editor
Plants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA
Interests: probiotics; bifidobacterium; bactobacillus; gut microbiome; CVD; diabetes; colitis; atherosclerosis; miRNA; drugs; antibiotic resistance; nutrients; metabolism; metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing global interest in nutraceuticals and medicine foods highlights their significant impact on human health, disease prevention, and metabolic regulation. Nutraceuticals, derived from natural food and/or plant sources, contain bioactive compounds such as fibers, essential fatty acids, vitamins, terpenoids, flavonoids, steroids, and alkaloids that contribute to overall well-being and chronic disease prevention. On the other hand, medicine foods are specifically formulated or engineered to offer targeted therapeutic benefits beyond basic nutrition. Examples include polyphenol-enriched beverages, cholesterol-lowering foods, medicinal mushrooms, and specialized dietary formulations for chronic disease management or treatment.

Recent advances in food science have led to the development of innovative medicine foods, including Maillard-derived low-sodium taste enhancers that support hypertension management and peptide-based flavour enhancers designed to reduce sugar intake, aiding diabetes control and metabolic health. Additionally, research into the gut microbiome, metabolomics, and epigenetic mechanisms has further revealed the complex interactions between nutraceuticals, metabolic pathways, and disease prevention.

This Special Issue aims to showcase cutting-edge research exploring how nutraceuticals and medicine foods influence human metabolism, chronic diseases management, and overall health. Topics of interest include bioactive compound isolation and characterization, functional food innovations, metabolic pathway modulation, and precision nutrition strategies. Studies incorporating novel analytical techniques, gut microbiome research, and metabolomic profiling are particularly encouraged.

We welcome submissions on a wide range of topics, including, but not limited to, the following:

  • Nutraceuticals and metabolic disease prevention;
  • Medicine foods and their therapeutic roles;
  • Bioactive compounds: isolation, characterization, and bioactivity;
  • Low-sodium and low-sugar food solutions;
  • Metabolic pathways influenced by nutraceuticals;
  • Innovations in analytical and metabolomic methodologies;
  • Functional food development for chronic disease management;
  • Epigenetic mechanisms and nutritional biochemistry;
  • Probiotics, gut microbiome, and metabolic disorders.

This Special Issue aims to present cutting-edge research bridging food science, nutrition, and human health.

Prof. Dr. Arun K. Bhunia
Prof. Dr. Antonello Santini
Dr. Junhe Yu
Dr. Salar Hafez Ghoran
Dr. Fatemeh Taktaz
Dr. Ahmad Ud Din
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceuticals
  • antioxidants
  • bioactive compounds
  • chronic disease prevention
  • epigenetics
  • functional foods
  • gut microbiome
  • human metabolism
  • food processing and the Maillard reaction
  • metabolomics
  • precision nutrition

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

13 pages, 501 KiB  
Systematic Review
Bioactive Properties of Hazelnut-Derived Products in Colorectal Cancer Prevention: A Systematic Review of Preclinical and Epidemiological Studies
by Giuseppe Mazzola, Mariangela Rondanelli, Federico Buga, Patrizia Riso and Simone Perna
Foods 2025, 14(13), 2154; https://doi.org/10.3390/foods14132154 - 20 Jun 2025
Abstract
Background: Colorectal cancer (CRC) is among the leading causes of cancer-related mortality worldwide, with increasing attention being paid to modifiable dietary factors in its prevention. Hazelnut (Corylus avellana L.) represent a nutrient-dense food rich in unsaturated fats, polyphenols, fiber, and phytosterols, [...] Read more.
Background: Colorectal cancer (CRC) is among the leading causes of cancer-related mortality worldwide, with increasing attention being paid to modifiable dietary factors in its prevention. Hazelnut (Corylus avellana L.) represent a nutrient-dense food rich in unsaturated fats, polyphenols, fiber, and phytosterols, with potential anticarcinogenic properties. This systematic review aimed to evaluate the role of hazelnut consumption in the prevention and modulation of CRC risk, with specific focus on experimental, mechanistic, and preclinical evidence. Methods: Following PRISMA guidelines, a systematic search was conducted in PubMed, Google Scholar, and the Cochrane Library for articles published from 2015 onward. Eligible studies included original in vitro and in vivo models, as well as observational studies, evaluating hazelnut or hazelnut-derived products in relation to CRC-related biological, metabolic, or clinical outcomes. Data extraction focused on bioactive composition, experimental models, molecular pathways, and fecal/metabolic markers of carcinogenesis. Results: A total of 11 studies were included after screening 24 records: 8 in vitro investigations, 2 in vivo animal experiments, and 1 epidemiological study. In vitro studies showed that hazelnut derivatives—including fermented hazelnuts and oil-based extracts—exert antiproliferative effects via BAX/BCL-2 modulation, increased caspase-3 activity, and oxidative stress reduction. In vivo studies confirmed improved lipid metabolism, modulation of bile acid composition (notably reduced lithocholic/deoxycholic acid ratio), and enhanced antioxidant defenses. FIBEROX®, a hazelnut skin extract enriched in dietary fiber, demonstrated promising effects on gut microbiota and bile acid detoxification. Conclusions: Hazelnut and their bioactive compounds may aid CRC prevention through multiple molecular and metabolic pathways. Further human studies are needed to confirm these effects and support dietary recommendations. Full article
Show Figures

Figure 1

Back to TopTop