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Advances in the Diagnosis and Management of Musculoskeletal Tumors

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Dear Colleagues,

The diagnosis and management of musculoskeletal tumors remain challenging due to the large number of histologies and variety of radiological findings. Over the past 50 years, new diagnostic devices have been developed and implemented, and physicians have continuously strived to improve the accuracy of diagnosis and the management of musculoskeletal tumors.

This Special Issue invites original papers and review articles that explore new techniques in diagnostic devices, surgery, and radiotherapy. Submissions on chemotherapy and immunotherapy aimed at improving survival in patients with musculoskeletal tumors, including metastatic bone tumors, are also encouraged.

Both basic and clinical research are welcome. I look forward to receiving your contributions.

Dr. Tomoki Nakamura
Guest Editor

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12 pages, 482 KB

Open AccessArticle

Clinical Diagnosis and Treatment in Patients with Schwannoma at a Single Institute

by Tomoki Nakamura, Ryohei Adachi, Tomohito Hagi, Yumi Matsuyama, Hironori Date and Masahiro Hasegawa

Diagnostics 2026, 16(15), 2299; https://doi.org/10.3390/diagnostics16152299 - 23 Jul 2026

Viewed by 1570

Abstract

Background/Objectives: The aim of this study was to review the clinical course of schwannoma in 176 patients and elucidate the clinical outcome in a patient who received surgical treatment and one who did not. Methods: Between August 2006 and December 2021, 176 patients with solitary and sporadic schwannomas were enrolled in our institution. There were 94 men and 82 women, with a mean age of 57 years. During follow-up, 76 patients received surgical treatment, and the remaining 100 did not. Results: The mean tumor size at initial presentation was 30 mm. The major tumor locations were the thigh, lower leg, upper arm, and forearm. The major nerves affected by the schwannoma were the intramuscular branch, sciatic nerve, and ulnar nerve. At least one symptom in addition to a palpable mass was observed in 133 patients (76%). The variables that indicated surgical treatment were tumor size at initial presentation, age, and any other existing symptoms. After surgery, pain-related symptoms including pain, irradiated pain and tenderness were resolved completely in 42 of 44 patients (95%) who had displayed them preoperatively. Neurological deficit was observed in 26 patients (34%). Among the 26 patients with neurological deficit, neurological sensory deficit was observed in 23 patients, and the remaining three had sensory and motor deficits. Multivariate analysis showed that patients with major nerve schwannoma, those with paresthesia preoperatively, and those who developed preoperative symptoms and had undergone surgery had a higher risk of the development of postoperative neurological deficit. Conclusions: Our findings should be considered while planning surgery and obtaining informed consent. Full article

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Musculoskeletal Tumors)

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