Recent Advances in Diagnosis and Treatment of CNS Tumours

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (29 September 2023) | Viewed by 2109

Special Issue Editor


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Guest Editor
Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy
Interests: neuropathology; brain tumors; epilepsy neuropathology; glioma; pituitary yumors; primary angiitis of the central nervous system

Special Issue Information

Dear Colleagues, 

The 2021 World Health Organization (WHO) classification significantly changed Central Nervous System (CNS) tumours classification. Improvements have been performed in the characterization of CNS tumors to predict survival outcomes. Novel therapeutic approaches, based on cancer biology, are increasingly being used, with promising results on tumor treatment.

This Special Issue will examine innovative approaches to the diagnosis and treatment of CNS tumors.

Researchers are encouraged to submit original research articles on (1) new insights into tissue-based biomarkers and recent advances in CNS tumours diagnosis, stratification, management, and drug development; (2) liquid biopsy; (3) progress in surgical techniques; (4) radiotherapy; (5) clinical trials and immunotherapy; (6) quality of life during and after the treatments; (7) CNS metastases.

Dr. Gianluca Marucci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain tumors
  • liquid biopsy
  • neurosurgery
  • neuroimaging
  • pathology
  • gliomas
  • glioblastoma
  • meningioma
  • ependymoma
  • genomics
  • radiomics
  • proteomics
  • medulloblastoma
  • ependymoma
  • secondary malignancies of the CNS
  • neuro-oncology

Published Papers (1 paper)

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13 pages, 1336 KiB  
Systematic Review
Clinical Applications of TSPO PET for Glioma Imaging: Current Evidence and Future Perspective—A Systematic Review
by Luca Filippi, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci and Laura Evangelista
Diagnostics 2023, 13(10), 1813; https://doi.org/10.3390/diagnostics13101813 - 21 May 2023
Cited by 4 | Viewed by 1479
Abstract
Our aim was to provide a comprehensive overview of the existing literature concerning the clinical applications of positron emission computed tomography (PET) with radiopharmaceuticals targeting the translocator protein (TSPO) in gliomas. A literature search for studies about TSPO PET in the last 10 [...] Read more.
Our aim was to provide a comprehensive overview of the existing literature concerning the clinical applications of positron emission computed tomography (PET) with radiopharmaceuticals targeting the translocator protein (TSPO) in gliomas. A literature search for studies about TSPO PET in the last 10 years (from 2013 to February 2023) was carried out on PubMed, Scopus, and Web of Science using the following keywords: “PET” AND “Gliomas” AND “TSPO”. The Critical Appraisal Skills Program checklist for diagnostic test studies was used for testing the quality of selected papers. Ten articles were selected, encompassing 314 glioma patients submitted to PET/CT (9/10) or PET/MRI (1/10) with TSPO ligands. Among the various available TSPO tracers, the most frequently used was the third-generation ligand, [18F]-GE-180. TSPO PET results were useful to identify anaplastic transformation in gliomas and for the prognostic stratification of patients bearing homogeneous genetic alterations. When compared to amino-acid PET, TSPO PET with [18F]-GE-180 presented superior image quality and provided larger and only partially overlapping PET-based volumes. Although biased by some issues (i.e., small sample size, most of the studies coming from the same country), preliminary applications of TSPO PET were encouraging. Further studies are needed to define implications in clinical practice and shape the role of TSPO PET for patients’ selection for potential TSPO-targeted molecular therapies. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of CNS Tumours)
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