Advances in the Diagnosis and Pathogenesis of Diabetes

Dear Colleagues,

Diabetes Mellitus is a metabolic disease whose prevalence is on the rise worldwide. It includes type 1, type 2, and gestational diabetes and some rare forms such as monogenic diabetes syndrome or drug-induced diabetes, the precursory condition of this disease being pre-diabetes. In spite of the high prevalence, most affected subjects are unaware of the disease, thus leading to progression and further complications such as neuropathy, retinopathy, nephropathy, cardiovascular disease and complications in the oral cavity (increased infection risk, delayed wound healing, periodontal disease, halitosis, dental caries, salivary and taste dysfunction, tongue abnormalities, oral cancer, temporomandibular disorders) that can further affect the patients’ quality of life.

Both pre-diabetes and diabetes are most frequently diagnosed by analyzing glucose levels, through fasting plasma glucose test and oral glucose tolerance test however, these methods do not distinguish between type 1 and 2 diabetes.

Other minimally invasive approaches include breath analysis, SwEatch, the glucose-sensing patch, and eyeglass biosensor to name a few. As such, novel diagnostic methods are necessary to identify and monitor various types of modifications before disease onset. Progress in selective biomarker signatures detection could support the prompt identification and classification of diabetic conditions and treatments, to prevent and reverse pre-diabetes. Moreover, diagnostic accuracy is thorough out the monitoring phase of treatment in order to assess efficacy and combat complications.

This special issue aims to offer an update on the current knowledge of diagnostic methods of diabetes, complications of diabetes, but also methods of monitoring treatment effectiveness.

In this special issue, we welcome researchers to submit either original research or reviews for publication in the upcoming Special Issue of the Diagnostics journal, especially, but not limited to, theoretical and clinical studies on new and established diagnostic methods and treatment effectiveness evaluation.

Prof. Dr. Liliana-Georgeta Foia
Dr. George Alexandru Maftei
Dr. Cristiana Elena Vlad
Guest Editors

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