Molecular and Pathophysiological Mechanisms Underlying Asthma and Allergy in Children: Latest Advances

Dear Colleagues,

Despite many advances being made in the field of allergy and asthma research, our understanding of the mechanisms involved in the development, pathophysiology, and specific clinical manifestations of allergic diseases is still insufficient. Allergic diseases in children are a major global health issue and their prevalence continues to increase globally. The key factors driving this increase remain elusive. Asthma and allergic diseases are the most common chronic conditions in children, having a significant impact on the quality of life of patients, their families, and caregivers. Allergic diseases such as food allergy, atopic dermatitis, asthma, and allergic rhinitis are prototypical examples of conditions in which pathogenesis is a result of a complex interaction of intrinsic (genetic and epigenetic) and environmental factors. Although novel treatments for allergic diseases (such as biologicals) have already been introduced into routine clinical practice, overall, the management of allergic diseases mostly relies on symptomatic treatment and allergen avoidance/elimination, which additionally reduces patients’ quality of life. Gaining a better insight into this pathogenesis is crucial for optimizing the current and developing new and improved management and prevention strategies in relation to allergic diseases.

Dr. Ivana Banić
Prof. Dr. Mirjana Turkalj
Guest Editors

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