Endothelial Cell Dysfunction and Multi-Organ Injury: From Molecular Mechanisms to Therapeutic Interventions

Dear Colleagues,

Endothelial cells are lined up in all the organs of the human body. Multiple factors can cause endothelial dysfunction, including cell activation, inflammation, and death. Systemic endothelial dysfunction contributes to organ injury and death. However, the long-term effects on the endothelial lining of the blood vessels themselves have been largely ignored for a long time, even though endothelial cells (EC) seem to be the primary site of acute inflammation. In atherosclerosis, another more common disease of blood vessels, EC injury, is viewed as the first stage in the complex process of atherogenesis according to the “response to injury” paradigm. As a consequence, widespread EC dysfunction (ECD) occurs, which seems to be persistent and a major contributor to the disease process. However, the molecular mechanisms of endothelial cell dysfunction and its contribution to multiorgan injury as well as therapeutic intervention are largely unknown and urgently require further research. This Topical Collection will include recent research advances on this topic.

Dr. Mingui Fu
Dr. Yisong Qian
Prof. Dr. Zhi-Sheng Jiang
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.