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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4810 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3918 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3726 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Skeletal Muscle: Structure, Physiology and Diseases

edited by

Vincenzo Sorrentino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3682 | Submission Open

Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging

(This special issue belongs to the Section Tissues and Organs)

Cell Therapeutics for Corneal Diseases

edited by

Dimitrios Karamichos

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3149 | Submission Open

Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair

(This special issue belongs to the Section Tissues and Organs)

Unconventional T Cells in Health and Disease

edited by Lauren Howson

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2841 | Submission Open

Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2353 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms in Oral Cavity Homeostasis and Disease

edited by

Mohamed Mekhemar

submission deadline 28 Feb 2026 | 3 articles | Viewed by 1419 | Submission Open

Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 28 Feb 2026 | Viewed by 1366 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1249 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 28 Feb 2026 | 3 articles | Viewed by 962 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 28 Feb 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in Microfluidics and Organoids for Biomedical Applications

edited by Lionel Fernel Gamarra

submission deadline 28 Feb 2026 | 1 articles | Viewed by 514 | Submission Open

Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells

(This special issue belongs to the Section Tissues and Organs)

Novel Insights into Neuroinflammation and Related Diseases

edited by Tahmineh Mokhtari

submission deadline 28 Feb 2026 | Viewed by 346 | Submission Open

Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies

(This special issue belongs to the Section Cellular Neuroscience)

Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies

edited by

Asad Jan

and Sara Elfarrash

submission deadline 28 Feb 2026 | Viewed by 278 | Submission Open

Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics

(This special issue belongs to the Section Cellular Aging)

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 28 Feb 2026 | Viewed by 260 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 28 Feb 2026 | Viewed by 215 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 28 Feb 2026 | Viewed by 199 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 28 Feb 2026 | Viewed by 178 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Microautophagy: The Least Known of the Autophagy Strategies

edited by

Patrice X. Petit

submission deadline 28 Feb 2026 | Viewed by 176 | Submission Open

Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs

(This special issue belongs to the Section Autophagy)

Lung Development: Challenges and Opportunities

edited by David Warburton

submission deadline 28 Feb 2026 | Viewed by 146 | Submission Open

Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration

(This special issue belongs to the Section Tissues and Organs)

Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders

edited by

Muhammad Nauman Arshad

and

Bruce Carter

submission deadline 28 Feb 2026 | Viewed by 140 | Submission Open

Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay

Molecular Insights into Inherited Metabolic Disorders

edited by Paul Gissen

submission deadline 28 Feb 2026 | Viewed by 111 | Submission Open

Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks

(This special issue belongs to the Section Cellular Metabolism)

Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies

edited by

Bogdan Pavel

and

Mingui Fu

submission deadline 28 Feb 2026 | Viewed by 110 | Submission Open

Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics

(This special issue belongs to the Section Cellular Pathology)

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Advanced Cell-Analyzing Technologies and Their Biosensing Applications

edited by

Tiean Zhou

and

Linhong Deng

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: cell analysis; biosensors; single-cell technologies; microfluidics; organ-on-a-chip; AI-driven biosensing diagnostics; nanotechnology; cell mechanics; cellular function analysis; cell phenotype assays

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 1 Mar 2026 | 1 articles | Viewed by 323 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 9 Mar 2026 | Viewed by 281 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 10 Mar 2026 | 1 articles | Viewed by 2314 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

α-Synuclein in Parkinson’s Disease

edited by

Maria Ilenia De Bartolo

and

Matteo Costanzo

submission deadline 10 Mar 2026 | 1 articles | Viewed by 582 | Submission Open

Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience

Targeting Tumor Suppressor Genes for Cancer Therapy

edited by Jogendra Pawar, Smita Kumari and Naseem Akhter

submission deadline 10 Mar 2026 | Viewed by 421 | Submission Open

Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine

Omics Technologies for Understanding Cell Pathophysiology

edited by

Ciro Isidoro

Annalisa Chiocchetti

and

Alessandra Ferraresi

submission deadline 10 Mar 2026 | Viewed by 419 | Submission Open

Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Endothelial Dysfunction in Vascular Diseases

edited by Antonio Nesci

submission deadline 10 Mar 2026 | Viewed by 202 | Submission Open

Keywords: endothelial dysfunction; vascular diseases; atherosclerosis; oxidative stress; nitric oxide; hypertension; vascular inflammation; endothelial repair

Neural Governance of Gastrointestinal Motility

edited by Jiande Chen

submission deadline 10 Mar 2026 | Viewed by 178 | Submission Open

Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron– epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III

edited by

Ralf Weiskirchen

submission deadline 15 Mar 2026 | 7 articles | Viewed by 24590 | Submission Open

(This special issue belongs to the Section Tissues and Organs)

Oral Tissue Stem Cells in Regenerative Dentistry

edited by

Jelena Milasin

and

Miloš M. Lazarević

submission deadline 15 Mar 2026 | 6 articles | Viewed by 20255 | Submission Open

Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering

(This special issue belongs to the Section Stem Cells)

Nanofluidics, Nanopores, and Nanomaterials for Understanding Biology

edited by

Malgorzata A. Witek

submission deadline 15 Mar 2026 | 2 articles | Viewed by 4224 | Submission Open

Keywords: nanofluidics; nanopores; nanomaterials; biology; biochemistry; bioengineering; biotechnology; drug delivery; sequencing; reaction kinetics; single-molecule detection

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 15 Mar 2026 | 1 articles | Viewed by 2576 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Mar 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Glioblastoma Cells: From Cellular and Molecular Mechanisms to Innovative Therapy—2nd Edition

edited by

Antonella Arcella

submission deadline 15 Mar 2026 | Viewed by 491 | Submission Open

Keywords: glioma; glioblastoma; glioma stem cells (GSCs); MGMT methylation; EGFR signaling; apoptosis; autophagy; molecular-targeted therapy; personalized medicine; radiotherapy; glioma cell biology; prognostic biomarkers; in vitro glioma models; in vivo glioblastoma studies

Glioblastoma Horizons: Exploring Mechanisms and Advancing Therapeutic Strategies

edited by Yang Wu and Julio Plata-Bello

submission deadline 15 Mar 2026 | Viewed by 416 | Submission Open

Keywords: glioblastoma heterogeneity; tumor microenvironment; 3D cell culture models; therapeutic resistance mechanisms; immunotherapy

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2026 | Viewed by 360 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Mar 2026 | Viewed by 311 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies

edited by

Deepthi Rajendran Nair

and Sushma Kalmodia

submission deadline 15 Mar 2026 | Viewed by 140 | Submission Open

Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction

(This special issue belongs to the Section Tissues and Organs)

Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells

edited by Nina Semenova and

Juan Sebastián Yakisich

submission deadline 15 Mar 2026 | Viewed by 137 | Submission Open

Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Mar 2026 | Viewed by 113 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma

edited by

Dinesh Pradhan

submission deadline 15 Mar 2026 | Viewed by 108 | Submission Open

Keywords: skin cancer; melanoma; Merkel cell carcinoma; skin lymphoma; squamous cell carcinoma; Mycosis fungoides; adnexal tumors; Sebaceous carcinoma; cutaneous soft tissue tumors

Molecular Mechanisms and Therapeutic Strategies of Macular Degeneration

edited by

Sankarathi Balaiya

submission deadline 19 Mar 2026 | Viewed by 74 | Submission Open

Keywords: macular degeneration; RPE; sirtuin; HDAC; oxidative stress; antioxidant; drusen; lipofuscin

Primary and Continued Cell Cultures

edited by

Xuefeng Liu

submission deadline 20 Mar 2026 | 5 articles | Viewed by 51355 | Submission Open

Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery

(This special issue belongs to the Section Cell Methods)

Displaying special issue 201-250 on page 5 of 14.

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