Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 March 2026 | Viewed by 18
Special Issue Editor
Interests: melanoma; cutaneous lymphoma; cancer genetics and epigenetics; molecular biology; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skin cancer is the most common cancer in the United States and worldwide. In the U.S., more than 5 million skin cancers are diagnosed annually, primarily nonmelanoma skin cancers such as basal cell and squamous cell carcinoma. Globally, skin cancers account for more than 40% of all cancer cases, with incidence rates rising over the past decades. Some of the skin cancers, such as melanoma and Merkel cell carcinoma, are aggressive diseases with 5-year relative survival of cases with distant metastasis as low as 35% and 21%, respectively.
Skin cancer has the highest tumor mutational burden and the highest objective response to immunotherapy (anti-PD-1 or anti-PD-L1 therapy). Numerous targeted therapies targeting known molecular alterations in melanoma have revolutionized its therapy. A better understanding of immunological abnormalities, molecular pathways, biomarkers, and epigenetics of melanoma has brought a paradigm shift in the management and survival of these patients.
The murine model of melanoma has better revealed the tumor immune microenvironment, elucidated the mechanism of PD-L1 depletion-induced cancer cell senescence via strong induction of stimulator of interferon genes (STING) expression, and it has demonstrated the potential of numerous immunomodulatory drugs.
Dr. Dinesh Pradhan
Guest Editor
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Keywords
- skin cancer
- melanoma
- Merkel cell carcinoma
- skin lymphoma
- squamous cell carcinoma
- Mycosis fungoides
- adnexal tumors
- Sebaceous carcinoma
- cutaneous soft tissue tumors
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