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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Decoding Melanoma: Molecular and Cellular Mechanisms and Therapeutic Opportunities

edited by

Cynthia Simbulan-Rosenthal

and

Anirudh Gaur

submission deadline 30 Oct 2026 | Viewed by 163 | Submission Open

Keywords: translational oncology; tumor biology; melanoma-targeted therapy; precision medicine; biomarker discovery

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Oct 2026 | 9 articles | Viewed by 19879 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology, and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4655 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

Immunoregulation in Cardiovascular Disease

edited by

Hong Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4353 | Submission Open

Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies

Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer

edited by Nicola Normanno,

Paola Ulivi

and

Tania Rossi

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4237 | Submission Open

Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence

Novel Immunotherapies for Diffuse Large B-Cell Lymphoma

edited by

Waseem Lone

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3786 | Submission Open

Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody–drug conjugates; tumor microenvironment; biomarkers; translational research

Spatial Biology: Decoding Cellular Complexity in Tissues

edited by

Alexander E. Kalyuzhny

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3445 | Submission Open

Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2650 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Signalling Mechanisms Regulating Cardiac Fibroblast Function

edited by Haofei Wang and

Yanhan Dong

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2619 | Submission Open

Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2160 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Molecular Signaling and Mechanism on Vascular Remodeling

edited by

Ki Ho Park

and Yitao Huang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2103 | Submission Open

Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling

Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease

edited by

Shabnam Nohesara

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1910 | Submission Open

Keywords: gut microbiome; epigenetic marks; cancer; metabolic diseases; neuropsychiatric disorders; inflammatory diseases; infectious diseases; cardiovascular diseases; probiotics; prebiotics

(This special issue belongs to the Section Cell and Gene Therapy)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1608 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Dictyostelium as a Model in Cell Dynamics and Disease

edited by

Ralph Gräf

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1092 | Submission Open

Keywords: dictyostelium; disease; cell migration; chemotaxis; cytoskeleton; cell mechanics; actin; host-bacteria interaction; cell division

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis

edited by

Sooyeon Lee

and

Mingyao Liu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 808 | Submission Open

Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial–mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 668 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Allergy and Immunity

edited by Anish R. Maskey and

Jan Geliebter

submission deadline 31 Oct 2026 | 1 articles | Viewed by 646 | Submission Open

Keywords: allergy; immune regulation; inflammation; epithelial barrier; biomarker; alternate therapy

(This special issue belongs to the Section Cellular Immunology)

Neurotoxicity: Focusing on Molecular and Cellular Mechanisms

edited by

Pablo Martín-Vasallo

, Manuel José Morales and

Rita Martín-Ramírez

submission deadline 31 Oct 2026 | Viewed by 460 | Submission Open

Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Oct 2026 | Viewed by 419 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

Mechanobiological Regulation of Fibroblast-to-Myofibroblast Phenotype Transition

edited by Mirko D’urso and

Nicholas A. Kurniawan

submission deadline 31 Oct 2026 | Viewed by 345 | Submission Open

Keywords: fibroblasts; myofibroblasts; mechanotransduction; extracellular matrix; fibrosis; tissue remodeling; mechanobiology

(This special issue belongs to the Section Cell Microenvironment)

Crosstalk Between Autophagy, Apoptosis and Inflammation

edited by

Maurizio Sorice

and

Tina Garofalo

submission deadline 31 Oct 2026 | Viewed by 306 | Submission Open

Keywords: autophagy; apoptosis; inflammation; signal transduction; lipid messengers; rheumatic disorders; cancer; neurodegenerative diseases

(This special issue belongs to the Section Autophagy)

Cellular and Molecular Mechanisms of Oocyte Maturation and the Fertilization Process

edited by

Luigia Santella

, Jong Tai Chun,

Evelyn Telfer

and Bart M. Gadella

submission deadline 31 Oct 2026 | Viewed by 305 | Submission Open

Keywords: oocyte growth; meiotic maturation; sperm capacitation; acrosome reaction; actin; calcium; cortical/zona reaction; polyspermy; cleavage; implantation

(This special issue belongs to the Section Reproductive Cells and Development)

Ovarian Tumors—Molecular Mechanisms, Cellular Dynamics, and Therapeutic Advances

edited by David Schweer, Joel Cardenas and

Delia Mezzanzanica

submission deadline 31 Oct 2026 | Viewed by 298 | Submission Open

Keywords: ovarian tumor biology; cellular signaling networks; genetic and epigenetic regulation; tumor microenvironment; cellular heterogeneity; single-cell and spatial omics; functional genomics; mechanisms of therapeutic resistance

(This special issue belongs to the Section Cellular Pathology)

Colorectal Cancer: Genetics and Molecular Mechanisms

edited by

Hala Gali-Muhtasib

and

Georgios Antonios Margonis

submission deadline 31 Oct 2026 | Viewed by 279 | Submission Open

Keywords: colorectal cancer; metastasis ; generation alterations; epigenetic regulation; signal transduction pathways; biomarkers; therapeutic resistance; in vitro and in vivo models; translational research

(This special issue belongs to the Section Tissues and Organs)

Autophagy, Mitochondria, and Cell Death in Cancer

edited by Yuchen Lei and

Kazuyuki Kitatani

submission deadline 31 Oct 2026 | Viewed by 274 | Submission Open

Keywords: autophagy; cancer; cell death; metabolism; mitochondria

(This special issue belongs to the Section Autophagy)

Advances in Alcohol-Associated Liver Disease

edited by

Sheetalnath Babasaheb Rooge

submission deadline 31 Oct 2026 | Viewed by 263 | Submission Open

Keywords: alcohol-associated liver disease (ALD); metabolic and alcohol associated liver disease (MetALD); alcohol-associated hepatitis (AH)；steatosis; fibrosis; cirrhosis; portal hypertension; hepatic inflammation; hepatocytes; macrophages; neutrophils; stellate cells

(This special issue belongs to the Section Cellular Pathology)

Nucleic Acids and Their Binding Partners: Structural and Mechanistic Insights

edited by

Rashmi Panigrahi

submission deadline 31 Oct 2026 | Viewed by 253 | Submission Open

Keywords: cryo-EM; NMR; AFM; molecular dynamics; nucleic acids; nucleic acid-protein complexes

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Ion Transporters and Channels in Cellular Homeostasis and Disease

edited by Guanxiao Qi and Raul E. Guzman

submission deadline 31 Oct 2026 | Viewed by 246 | Submission Open

Keywords: patch-clamp recording; ligand-gated channels; ion channel modulators; channel-specific ligands; channelopathies; epilepsy; neurodegenerative disease

Integrating CRISPR-Based Functional Genomics and Multi-Omics to Identify Therapeutic Targets

edited by

Farimah Ghorbani

and David J. Elliott

submission deadline 31 Oct 2026 | Viewed by 226 | Submission Open

Keywords: CRISPR-technology; functional genomics screening; Perturb-seq; multi-omics; disease mechanisms; drug target discovery

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms Behind Liver Inherited Metabolic Diseases and Novel Therapeutic Strategies

edited by Sonam Gurung

submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open

Keywords: inherited metabolic liver diseases; urea cycle disorders; hepatic metabolic homeostasis; molecular mechanisms of disease; disease-modifying therapies; monogenic disorders; systems biology approaches; rare diseases

(This special issue belongs to the Section Cellular Pathology)

Microscopy in Decoding Complex Cellular Structures

edited by

Marcus Frank

submission deadline 31 Oct 2026 | Viewed by 197 | Submission Open

Keywords: correlative microscopy; super resolution microscopy; electron microscopy; 3D reconstruction; cell–cell contact; cell–matrix contact; cell surface; cell signaling; cell microenvironment; cell adhesion; cell junction; cell organelle; organelle maturation; mitochondria; Golgi apparatus; phagosomes; cilia; synapse formation; barrier function; blood–brain barrier; multimodal microscopy; fluorescence microscopy; expansion microscopy; organelle shaping; migrasomes; protozoan; organoid; spheroid

(This special issue belongs to the Section Cell Methods)

Advanced Review Papers in ‘Tissue and Organs’

edited by

Chao Xie

submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open

Keywords: tissue biology; organ development and morphogenesis; tissue architecture and organization; stem cells and progenitor cells; tissue regeneration and repair; extracellular matrix; cell–cell communication; cellular microenvironment; tissue remodeling; 3D tissue models and bioengineering

(This special issue belongs to the Section Tissues and Organs)

The Role of Immune Checkpoint Inhibitors Combined with Cancer Vaccines in the Neoadjuvant Setting of Solid Tumors

edited by Yasser Mostafa Kamel and Mahmoud Abdelsalam

submission deadline 31 Oct 2026 | Viewed by 174 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors (ICIs); therapeutic cancer vaccines; early-stage solid tumors; pathologic complete response (pCR); major pathologic response (MPR)

(This special issue belongs to the Section Cellular Immunology)

Emerging Trends in Liquid Biopsy: Recent Advances and Challenges

edited by

Nurmaa Dashzeveg

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: liquid biopsy; circulating DNA (ctDNA); circulating tumor cells (CTC); blood; biofluid

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms of Sperm Capacitation

edited by Patricio J. Morales,

Héctor Zapata-Carmona

and Milene Kong

submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open

Keywords: sperm capacitation; acrosome reaction; protein phosphorylation; calcium signaling; signal transduction; post-translational modifications

(This special issue belongs to the Section Reproductive Cells and Development)

MicroRNAs in Atherosclerosis: Mechanisms, Biomarkers, and Therapeutic Opportunities

edited by Genesio Karere

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: microRNAs (miRNAs); atherosclerosis and vascular inflammation; endothelial dysfunction; circulating biomarkers; RNA-based therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Cellular and Molecular Responses to Abiotic and Biotic Stress in Plants

edited by

Akhilesh Yadav

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: abiotic stress; biotic stress; plants; stress signaling; plant immunity; gene regulation; plant–microbe interactions; stress physiology; genomics

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular and Molecular Mechanisms in Mammalian Reproduction

edited by

Kirsten E.S. Scoggin

Carleigh Elizabeth Fedorka

and

Hossam El Sheikh Ali

submission deadline 31 Oct 2026 | Viewed by 149 | Submission Open

Keywords: cell physiology; intra- and extracellular signaling; cell growth and differentiation; cellular immunology; stem cells; autophagy; apoptosis; omics; aging/senescence; cell techniques

(This special issue belongs to the Section Reproductive Cells and Development)

Epigenetic Regulation of Cellular Plasticity in Brain Tumors

edited by

Sree Deepthi Muthukrishnan

and Erina Vlashi

submission deadline 31 Oct 2026 | Viewed by 138 | Submission Open

Keywords: brain tumors; epigenetic modifiers; tumor plasticity; epigenetic heterogeneity; microenvironment-epigenetic interactions; therapy resistance

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Genetics of Cystic Kidney Disease

edited by

John Sayer

and Juliana Galvis

submission deadline 31 Oct 2026 | Viewed by 129 | Submission Open

Keywords: cystic kidney disease; polycystic kidney disease; cilia; PKD1; PKD2; autosomal dominant; renal epithelium; animal models; disease mechanisms; organoids

(This special issue belongs to the Section Cell and Gene Therapy)

Mechanisms of Drug Resistance in Colorectal Cancer

edited by

Steve Shnyder

submission deadline 31 Oct 2026 | Viewed by 115 | Submission Open

Keywords: colorectal cancer; drug resistance; chemotherapy; targeted therapy; tumour microenvironment; cancer stem cells; preclinical models; combination therapy; resistance mechanisms; predictive biomarkers

(This special issue belongs to the Section Cellular Pathology)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Nov 2026 | 2 articles | Viewed by 2333 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Role of Inflammasomes in Neurological Disorders

edited by

Juan Pablo de Rivero Vaccari

submission deadline 1 Nov 2026 | Viewed by 330 | Submission Open

Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’s disease; Parkinson’s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by

Joaquim Gea Guiral

submission deadline 5 Nov 2026 | 3 articles | Viewed by 7531 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 5 Nov 2026 | Viewed by 523 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial–mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 10 Nov 2026 | 3 articles | Viewed by 10243 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies

edited by

Wei Du

and

Pier Paolo Piccaluga

submission deadline 10 Nov 2026 | 2 articles | Viewed by 4484 | Submission Open

Keywords: hematologic diseases; mechanisms; therapies

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 Nov 2026 | 3 articles | Viewed by 2692 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Molecular and Cellular Mechanisms of Heart Regeneration

edited by Mira Pronobis and

Dinender K. Singla

submission deadline 10 Nov 2026 | 1 articles | Viewed by 1123 | Submission Open

Keywords: cardiac regeneration; cardiomyocyte proliferation; tissue remodeling; cardiovascular repair; regenerative therapy; cellular plasticity; myocardial infarction; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 10 Nov 2026 | Viewed by 472 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

Displaying special issue 251-300 on page 6 of 12.

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