Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7308 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 3 articles | Viewed by 6937 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6149 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6133 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 5233 | Submission Open
Keywords: cell biology; physiology; molecular biology
Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience
edited by Howard Prentice and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4850 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cells of the Nervous System)
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4685 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4301 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 3555 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3355 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2739 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2650 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | 1 articles | Viewed by 2509 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | 2 articles | Viewed by 2432 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1910 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1829 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1646 | Submission Open
Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites
(This special issue belongs to the Section Cells of the Nervous System)
Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1596 | Submission Open
Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity
(This special issue belongs to the Section Cellular Immunology)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1447 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 1405 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1171 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1156 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1011 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
Epigenetic Mechanisms and Aging
edited by
submission deadline 31 Dec 2025 | Viewed by 449 | Submission Open
Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses
(This special issue belongs to the Section Cellular Aging)
Colorectal Cancer: Molecular Mechanisms and Treatment Progress
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 400 | Submission Open
Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 311 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 249 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
How Does Gene Regulation Affect Cancer Development? submission deadline 31 Dec 2025 | Viewed by 246 | Submission Open
Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs
(This special issue belongs to the Section Cell Microenvironment)
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Dec 2025 | Viewed by 211 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 31 Dec 2025 | Viewed by 208 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
Immunology and Immune Therapies for Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology
(This special issue belongs to the Section Cell Microenvironment)
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Traumatic Injury and Resolution submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open
Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics
(This special issue belongs to the Section Cellular Pathology)
Kinin System in Health and Disease: Cellular and Molecular Perspectives
edited by Marcos Gregnani and Leonardo Martins
submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open
Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities
edited by
submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open
Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Inflammation and Aging in Acute and Chronic Kidney Injury submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; inflammation; aging
(This special issue belongs to the Section Cellular Aging)
Hematopoietic Cell Lines as Models for Leukemia and Lymphoma
edited by Stefan Nagel
submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes
Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities
edited by and Dragana Jovanovic
submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open
Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy
(This special issue belongs to the Section Cell Microenvironment)
The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis
edited by
submission deadline 31 Dec 2025 | Viewed by 80 | Submission Open
Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis
(This special issue belongs to the Section Cellular Pathology)
Molecular and Genetic Pathogenesis of Hematological Disorders
edited by
submission deadline 10 Jan 2026 | 1 articles | Viewed by 1995 | Submission Open
Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
New Insights into Therapeutic Targets for Cardiovascular Diseases submission deadline 15 Jan 2026 | 3 articles | Viewed by 10916 | Submission Open
Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanisms of Lung Growth and Regeneration submission deadline 15 Jan 2026 | 1 articles | Viewed by 1524 | Submission Open
Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq
(This special issue belongs to the Section Cell Microenvironment)
Recent Progress on Fibrosis and Cardiac Dysfunction submission deadline 15 Jan 2026 | Viewed by 420 | Submission Open
Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies
edited by Stefania Belli, and
submission deadline 15 Jan 2026 | Viewed by 119 | Submission Open
Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer
(This special issue belongs to the Section Cell Microenvironment)
New Insights into Gene Research and Therapy for Diabetes Mellitus submission deadline 15 Jan 2026 | Viewed by 106 | Submission Open
Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors
Oral Stem Cells in Regenerative Biology
edited by
submission deadline 15 Jan 2026 | Viewed by 92 | Submission Open
Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells
(This special issue belongs to the Section Stem Cells)
Organ Regeneration: Cells, Organoids and Organs
edited by Jia Huang
submission deadline 15 Jan 2026 | Viewed by 87 | Submission Open
Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility
(This special issue belongs to the Section Tissues and Organs)
Signaling Pathways in Endometrial Cancer Cells
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 8631 | Submission Open
Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification
(This special issue belongs to the Section Cell Signaling)
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