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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Marfan Syndrome

edited by

Vivian De Waard

Gustavo Egea

and

María Galán

submission deadline 15 Sep 2025 | 4 articles | Viewed by 4076 | Submission Open

Keywords: Marfan syndrome; aortic aneurysm; aortic dissection; TGFβ ; BMP; matrix metalloproteinase; NO synthase; mitochondrial dysfunction; oxidative stress; endothelium; aortic vascular smooth muscle cells; phenotypic switching; adventitia; hemodynamics; gene therapy; connective tissue disease

(This special issue belongs to the Section Cellular Pathology)

Advancements in Immunotherapy and CAR T Cell Therapy: Unleashing the Power of the Immune System Against Cancer

edited by

Pradeep K. Shukla

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1154 | Submission Open

Keywords: CAR T; immunotherapy; cancer; chimeric antigen receptors

(This special issue belongs to the Section Cellular Immunology)

In Vitro Model for Micro- and Nano-Technologies—Second Edition

edited by Tania Limongi

submission deadline 15 Sep 2025 | Viewed by 142 | Submission Open

Keywords: in vitro cell culture; micro- and nano-technology; extracellular vesicles; nanoparticles; quantum dots; biocompatibility; hemocompatibility; diagnosis; drug delivery; tissue engineering

(This special issue belongs to the Section Cellular Biophysics)

Cancer Cell Signaling, Autophagy and Tumorigenesis

edited by Debanjan Bhattacharya

submission deadline 15 Sep 2025 | Viewed by 79 | Submission Open

Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway

Molecular and Cellular Advances in Gut-Brain Axis

edited by

Aditi Bhargava

and Radhakrishna Rao

submission deadline 20 Sep 2025 | 2 articles | Viewed by 26110 | Submission Open

Keywords: gut– brain axis; microbiome; omics; diet; biological sex; gender; early-life stress; immunity; mental health; neurodegenerative diseases; metabolic health

(This special issue belongs to the Section Cells of the Nervous System)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2831 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Advances in Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Raheleh Roudi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2686 | Submission Open

Keywords: non-small cell lung cancer; immunotherapy; immune checkpoint inhibitors; PD-1; PD-L1; pembrolizumab; nivolumab; atezolizumab; CTLA4

(This special issue belongs to the Section Cellular Immunology)

Gene and Cellular Signaling Related to Muscle

edited by

Khurshid Ahmad

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1920 | Submission Open

Keywords: skeletal muscle; molecular mechanism; muscle atrophy; therapeutics; metabolic signals; satellite cells

(This special issue belongs to the Section Cell Signaling)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 20 Sep 2025 | Viewed by 306 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

Macrophage-Epithelial Interplay in Pulmonary Fibrosis

edited by

Negah Ahmadvand

and Farhad Khosravi

submission deadline 20 Sep 2025 | Viewed by 244 | Submission Open

Keywords: macrophages; epithelial cells; idiopathic pulmonary fibrosis (IPF); immune response

The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation

edited by

Vinay Shukla

submission deadline 20 Sep 2025 | Viewed by 108 | Submission Open

Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation

(This special issue belongs to the Section Tissues and Organs)

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 20 Sep 2025 | Viewed by 91 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis

edited by Alessandra Loda and

Paola Bagnoli

submission deadline 25 Sep 2025 | 1 articles | Viewed by 2024 | Submission Open

Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors

Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance

edited by

Yang Xu

and Ramkrishna Mitra

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1367 | Submission Open

Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations

(This special issue belongs to the Section Cellular Pathology)

Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease

edited by

Roger Schneiter

and Museer Ahmad Lone

submission deadline 25 Sep 2025 | Viewed by 435 | Submission Open

Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation

(This special issue belongs to the Section Cellular Biophysics)

Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision

edited by

Luminita Paraoan

and Janet R. Sparrow

submission deadline 25 Sep 2025 | Viewed by 398 | Submission Open

Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration

(This special issue belongs to the Section Tissues and Organs)

Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome

edited by Eytan R. Barnea,

Nicoletta Di Simone

and Guarano Alice

submission deadline 25 Sep 2025 | Viewed by 378 | Submission Open

Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control

(This special issue belongs to the Section Tissues and Organs)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 25 Sep 2025 | Viewed by 257 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Ovarian Microenvironment and Oocyte Quality: Mechanisms, Aging, and Therapeutic Strategies

edited by Haiyang Wang

submission deadline 25 Sep 2025 | Viewed by 103 | Submission Open

Keywords: ovarian microenvironment; oocyte; mechanisms; aging; therapeutic strategies

(This special issue belongs to the Section Cell Microenvironment)

Amyloid–Metal Interactions in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Advances

edited by

Jonathan Pansieri

submission deadline 25 Sep 2025 | Viewed by 77 | Submission Open

Keywords: Alzheimer’ s; amyloids; Aß ; Tau; neurodegeneration; metal homeostasis; oxidative stress; neuropathology; PET

(This special issue belongs to the Section Cellular Aging)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Sep 2025 | Viewed by 156 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders

edited by

Györgyi Műzes

and

Ferenc Sipos

submission deadline 30 Sep 2025 | 5 articles | Viewed by 20289 | Submission Open

Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections

(This special issue belongs to the Section Cellular Immunology)

Unlocking the Secrets Behind Drug Resistance at the Cellular Level

edited by

Sara Ricardo

and

Cristina Pinto Ribeiro Xavier

submission deadline 30 Sep 2025 | 4 articles | Viewed by 9873 | Submission Open

Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance

(This special issue belongs to the Section Cellular Immunology)

Research on T Cells in Skin Inflammatory Disorders

edited by

Henry K. Wong

and Qing-Sheng Mi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 5330 | Submission Open

Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma

(This special issue belongs to the Section Cellular Immunology)

Eosinophils and Their Role in Allergy and Related Diseases

edited by

Paige Lacy

submission deadline 30 Sep 2025 | 5 articles | Viewed by 5155 | Submission Open

Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release

(This special issue belongs to the Section Cellular Immunology)

Onco-Hematology and Immunotherapy

edited by

Jean Gabert

and Régis T. Costello

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4940 | Submission Open

Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas

(This special issue belongs to the Section Cellular Immunology)

Antioxidants in Redox Homeostasis of Plant Development

edited by

Dragana Z. Jakovljević

and

Milan Stankovic

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4238 | Submission Open

Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3372 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3218 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Autophagy and Tumor Microenvironment

edited by

Maria Condello

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3090 | Submission Open

Keywords: autophagy; cancer growth; cancer therapy; chemoresistance; microenvironment

(This special issue belongs to the Section Autophagy)

Sebaceous Gland in Skin Health and Disease

edited by

Stefania Briganti

and Monica Ottaviani

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2926 | Submission Open

Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics

(This special issue belongs to the Section Cellular Pathology)

Cell Biology: State of the Art and Perspectives in Italy 2025

edited by

Vincenzo Carafa

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2519 | Submission Open

Keywords: cell biology; physiology; molecular biology

Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition

edited by

Yutaka Hirose

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2233 | Submission Open

Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Pathogenesis of Diabetic Kidney Disease

edited by Jia Fu

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1752 | Submission Open

Keywords: diabetic kidney disease (DKD); molecular mechanism; oxidative stress; chronic kidney disease; pathogenesis; diagnostic and therapeutic strategies; inflammation; metabolic dysfunction

(This special issue belongs to the Section Cellular Pathology)

Molecular Pathogenesis of Cardiovascular Diseases

edited by

Guo-Chang Fan

Ao Shi

and Chen Gao

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1682 | Submission Open

Keywords: cardiovascular diseases (CVDs); molecular pathogenesis; inflammation; fibrosis; cell death; genetic factors; extracellular vesicle; environmental factors; myocardial infarction; atherosclerosis; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

CRISPR-Based Genome Editing in Translational Research—Third Edition

edited by

Jie Xu

Dongshan Yang

and Jifeng Zhang

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1602 | Submission Open

Keywords: genome; gene editing; CRISPR/Cas9

Organellar Ca²⁺ Transport in Plant versus Animal Cells: Can We Learn from Each Other?

edited by Shey-Shing Sheu and Marc Freichel

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1592 | Submission Open

Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging

(This special issue belongs to the Section Cell Microenvironment)

Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management

edited by Luca Antonioli and

Clelia Di Salvo

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1324 | Submission Open

Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP

Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease

edited by Ki Ho Park

submission deadline 30 Sep 2025 | 1 articles | Viewed by 983 | Submission Open

Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Artificial Intelligence to the Rescue of Cancer Research

edited by

Asunción Espinosa-Sánchez

and

Amancio Carnero

submission deadline 30 Sep 2025 | 1 articles | Viewed by 915 | Submission Open

Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine

(This special issue belongs to the Section Cell Methods)

Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia

edited by

Mookon Song

submission deadline 30 Sep 2025 | 1 articles | Viewed by 904 | Submission Open

Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation

(This special issue belongs to the Section Cellular Pathology)

The Role of Epithelial Cells in Scleroderma—Second Edition

edited by Richard Stratton

submission deadline 30 Sep 2025 | 1 articles | Viewed by 833 | Submission Open

Keywords: fibrosis; epithelial– fibroblast interaction; EMT; cytokeratin 6 and 16

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 30 Sep 2025 | 1 articles | Viewed by 830 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Melanoma: From Molecular Mechanisms to Therapeutic Opportunities—3rd Edition

edited by

Cynthia Simbulan-Rosenthal

and

Dean S. Rosenthal

submission deadline 30 Sep 2025 | 1 articles | Viewed by 802 | Submission Open

Keywords: melanomagenesis; treatment response; signal transduction; melanoma-initiating cells; drug resistance; invasiveness; immune evasion; metastasis; MAPK pathway; PI3K/AKT survival pathways; MEKi; BRAFi; trametinib; dabrafenib; immunotherapies

(This special issue belongs to the Section Cellular Pathology)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 30 Sep 2025 | 1 articles | Viewed by 584 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Contribution of Omics Sciences to Agricultural Biotechnology

edited by

Sara Rinalducci

Nunzio D'Agostino

and

Giuseppina Fanelli

submission deadline 30 Sep 2025 | Viewed by 382 | Submission Open

Keywords: omics technologies; bioinformatics; systems biology; data mining; knowledge discovery; metabolic engineering; genetic engineering; plant biotechnologies; agrifoods; (a)biotic stress resilience; plant– microbe interactions

(This special issue belongs to the Section Cell Methods)

mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact

edited by

Stefano Zoroddu

and

Luigi M. Bagella

submission deadline 30 Sep 2025 | Viewed by 364 | Submission Open

Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems

(This special issue belongs to the Section Cellular Pathology)

Progress of Nanoparticles in the Treatment of Cancers

edited by

Mohammad Asif Sherwani

submission deadline 30 Sep 2025 | Viewed by 313 | Submission Open

Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Yeast Stress Responses and Cell Death Regulation

edited by

Maria João Sousa

Manuela Côrte-Real

and

Susana R. Chaves

submission deadline 30 Sep 2025 | Viewed by 280 | Submission Open

Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death

Spatial Biology: Decoding Cellular Complexity in Tissues

edited by