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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Organoids as an Experimental Tool

edited by

Ralf Weiskirchen

Leo A. Van Grunsven

and Anjali A. J. Roeth

submission deadline 10 Jul 2025 | 8 articles | Viewed by 14527 | Submission Open

Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids

(This special issue belongs to the Section Tissues and Organs)

Sickle Cell Disease: Pathogenesis, Diagnosis and Treatment

edited by Vivien Sheehan and Ben Kopp

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1494 | Submission Open

Keywords: sickle cell disease; vaso-occlusive events; acute chest syndrome; omics; gene therapy; red cell rheology; microfluidics

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular Mechanisms and Therapy of Asthma

edited by

Marco Caminati

submission deadline 15 Jul 2025 | 6 articles | Viewed by 26321 | Submission Open

(This special issue belongs to the Section Cellular Pathology)

Inflammation in Target Organs

edited by

Itamar Raz

and Roni Weinberg Sibony

submission deadline 15 Jul 2025 | 6 articles | Viewed by 14520 | Submission Open

Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain

(This special issue belongs to the Section Cellular Immunology)

Advances in the Biogenesis, Biology, and Functions of Noncoding RNAs

edited by Xinguo Chen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 7756 | Submission Open

Keywords: noncoding RNA biogenesis; long noncoding RNA (lncRNAs); circular RNA (circRNAs); enhancer RNA (eRNAs); microRNA (miRNAs); PIWI-interacting RNAs (pi-RNAs); tRNA-derived fragments (tRFs)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 15 Jul 2025 | 1 articles | Viewed by 918 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Jul 2025 | Viewed by 290 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Browning of Adipocytes in Metabolic Health and Disease

edited by You Lee Son and Yuko Okamatsu-Ogura

submission deadline 15 Jul 2025 | Viewed by 163 | Submission Open

Keywords: brown and white adipose tissue; BAT; and WAT; brown; beige; and white adipocyte; browning of white adipocyte; adipocyte differentiation; adipose tissue remodeling; adipose hyperplasia and hypertrophy; metabolic disorders; obesity; aging; inflammation

(This special issue belongs to the Section Cellular Pathology)

Decoding Cancer Metabolism: Recent Insights and Future Directions

edited by Parash Prasad and Snehasis R. Mishra

submission deadline 15 Jul 2025 | Viewed by 144 | Submission Open

Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing

Molecular Mechanisms of Neuropathic Pain

edited by

Hiroshi Ueda

and

Norimitsu Morioka

submission deadline 20 Jul 2025 | 8 articles | Viewed by 10024 | Submission Open

Keywords: neuropathic pain; nociplastic pain; fibromyalgia; brain-immune connection; sexual dimorphism; glial cells; lysophosphatidic acid

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6330 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jul 2025 | 2 articles | Viewed by 3685 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

Environmental Exposure and Cell Damage

edited by

Paola Piomboni

Alice Luddi

and

Melvin K. S. Leow

submission deadline 20 Jul 2025 | 1 articles | Viewed by 3529 | Submission Open

Keywords: cellular and molecular damage; oxidative stress; environmental effects; endocrine disruptors; lifestyle factors

(This special issue belongs to the Section Cellular Immunology)

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3023 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Jul 2025 | 3 articles | Viewed by 2296 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Advances in Intestinal Epithelial Plasticity and Regeneration

edited by

Aiguo Tian

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2192 | Submission Open

Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration

Role of Autophagy in Plant Cells

edited by

Alessio Papini

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2044 | Submission Open

Keywords: autophagy; endoplasmic reticulum; TOR; vacuoles; lysosomes; mitochondria; plastids

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Jul 2025 | 1 articles | Viewed by 723 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Host–Microbial Interactions: Second Edition

edited by

Hung-Jen Liu

Brent L. Nielsen

and

Muhammad Munir

submission deadline 20 Jul 2025 | Viewed by 651 | Submission Open

Keywords: virus– host interactions; signaling pathway; virus entry; life cycle

(This special issue belongs to the Section Cellular Immunology)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jul 2025 | Viewed by 137 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

Glioblastoma: What Do We Know?

edited by

Shan Ping Yu

submission deadline 25 Jul 2025 | 5 articles | Viewed by 12816 | Submission Open

Keywords: carcinoma cell; diagnoses; molecular mechanism; cellular mechanism; signaling pathways; biomarkers; therapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Jul 2025 | 6 articles | Viewed by 10561 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Regulation of Receptor Tyrosine Kinase Signaling and Its Implication in Cancer

edited by

Zhixiang Wang

submission deadline 25 Jul 2025 | 2 articles | Viewed by 3173 | Submission Open

Keywords: RTKs; EGFR family; PDGFR family; FGF receptor family; VEGFR family; growth factors; phosphorylation; cell signaling; cell cycle; cancer; targeted cancer therapy; the antibody-based cancer therapies; small molecule-based tyrosine kinase inhibitor (TKI)

(This special issue belongs to the Section Cell Signaling)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 25 Jul 2025 | 2 articles | Viewed by 3076 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cells of the Nervous System)

New Molecular and Computational Approaches to Study Immune and Metabolic Interactions in Cancer Biology

edited by Federica Mornata, Luca De Feo, Rebecca Polidori and

Matteo Brindisi

submission deadline 25 Jul 2025 | Viewed by 342 | Submission Open

Keywords: solid and liquid cancer; cancer metabolism; tumor microenvironment; digital pathology; immunoncology

(This special issue belongs to the Section Cell Methods)

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2025 | Viewed by 128 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jul 2025 | Viewed by 91 | Submission Open

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

Recent Developments in Cellular and Molecular Mechanisms and Therapeutic Approaches to Cardiovascular and Metabolic Diseases

edited by

Catherine Yzydorczyk

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1115 | Submission Open

Keywords: cardiometabolic diseases; developmental programming; sexual dimorphism

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 30 Jul 2025 | Viewed by 117 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

State-of-the-Art of Cell Cultures in Drug Validation and Toxicity Assessment

edited by

Anna Bassi

and

Stefania Vernazza

submission deadline 31 Jul 2025 | 7 articles | Viewed by 18856 | Submission Open

Keywords: human in vitro models; toxicity testing; drug development; mandatory requirements; regulatory approval; standardization; validation

(This special issue belongs to the Section Cell Methods)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 Jul 2025 | 4 articles | Viewed by 16184 | Submission Open

(This special issue belongs to the Section Cell Methods)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jul 2025 | 4 articles | Viewed by 10001 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 31 Jul 2025 | 3 articles | Viewed by 9007 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jul 2025 | 3 articles | Viewed by 6037 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4834 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

Cell–Cell Interactome-Based Therapies for Osteosarcoma

edited by

Frédéric Lézot

and Javier Munoz

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3792 | Submission Open

Keywords: osteosarcoma; cell– cell interactions; microenvironment; metastases; resistance; chemotherapy; immune checkpoints

(This special issue belongs to the Section Cell Microenvironment)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3516 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Ion Channels in Cancer: An Update

edited by

Michael X. Zhu

and

Yong Zhou

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2245 | Submission Open

Keywords: ion channels; cancer therapy; cancer cell biology; mitogenic signaling; cancer signaling

(This special issue belongs to the Section Cell Proliferation and Division)

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1093 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 31 Jul 2025 | 1 articles | Viewed by 951 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 31 Jul 2025 | 1 articles | Viewed by 932 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neuronal Development and Disease: From Molecular Bases to Neurological Disorders

edited by Ramiro Almeida

submission deadline 31 Jul 2025 | 1 articles | Viewed by 899 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Establishment and Characterization of Novel Patient-Derived Cancer Model

edited by

Yuki Yoshimatsu

and

Tadashi Kondo

submission deadline 31 Jul 2025 | 1 articles | Viewed by 409 | Submission Open

Keywords: patient-derived cancer model; primary tissue culture; cell line; spheroid; organoid; xenograft; PDX; organ-on-a-chip; comparative oncology; precision medicine

Retinal Pigment Epithelium in Degenerative Retinal Diseases

edited by Jian Liu and Shintaro Horie

submission deadline 31 Jul 2025 | Viewed by 390 | Submission Open

Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers

(This special issue belongs to the Section Cellular Pathology)

Therapeutic Applications of Magnetotactic Bacteria and Magnetosomes: State of the Art and Perspectives

edited by

Patrice X. Petit

submission deadline 31 Jul 2025 | Viewed by 306 | Submission Open

Keywords: biomedical applications; biotechnology; magnetite nanocrystals; magnetosomes; magnetotactic bacteria; nanotechnology; nanotargeting

(This special issue belongs to the Section Cellular Biophysics)

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 31 Jul 2025 | Viewed by 289 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Advances in Understanding Skeletal Muscle Metabolism and Regeneration: From Mechanisms to Therapeutics

edited by

Junaith S. Mohamed

submission deadline 31 Jul 2025 | Viewed by 249 | Submission Open

Keywords: skeletal muscle; satellite cells; myoblast; myogenesis; regeneration; mitochondria; metabolism; sarcopenia; cachexia

(This special issue belongs to the Section Tissues and Organs)

Mechanisms That Link Olfactory Perception with Aging in Drosophila

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jul 2025 | Viewed by 179 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 31 Jul 2025 | Viewed by 176 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 31 Jul 2025 | Viewed by 173 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

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