Submit to Cells Review for Cells Propose a Special Issue

Journal Menu

Journal Browser

Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

Section

Search by Title/Keyword

Order results

Display

Results per page

Glioblastoma Cells: From Cellular and Molecular Mechanisms to Innovative Therapy—2nd Edition

edited by

Antonella Arcella

submission deadline 15 Mar 2026 | Viewed by 495 | Submission Open

Keywords: glioma; glioblastoma; glioma stem cells (GSCs); MGMT methylation; EGFR signaling; apoptosis; autophagy; molecular-targeted therapy; personalized medicine; radiotherapy; glioma cell biology; prognostic biomarkers; in vitro glioma models; in vivo glioblastoma studies

Glioblastoma Horizons: Exploring Mechanisms and Advancing Therapeutic Strategies

edited by Yang Wu and Julio Plata-Bello

submission deadline 15 Mar 2026 | Viewed by 418 | Submission Open

Keywords: glioblastoma heterogeneity; tumor microenvironment; 3D cell culture models; therapeutic resistance mechanisms; immunotherapy

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2026 | Viewed by 370 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Mar 2026 | Viewed by 316 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies

edited by

Deepthi Rajendran Nair

and Sushma Kalmodia

submission deadline 15 Mar 2026 | Viewed by 151 | Submission Open

Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction

(This special issue belongs to the Section Tissues and Organs)

Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells

edited by Nina Semenova and

Juan Sebastián Yakisich

submission deadline 15 Mar 2026 | Viewed by 139 | Submission Open

Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Mar 2026 | Viewed by 117 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma

edited by

Dinesh Pradhan

submission deadline 15 Mar 2026 | Viewed by 111 | Submission Open

Keywords: skin cancer; melanoma; Merkel cell carcinoma; skin lymphoma; squamous cell carcinoma; Mycosis fungoides; adnexal tumors; Sebaceous carcinoma; cutaneous soft tissue tumors

Molecular Mechanisms and Therapeutic Strategies of Macular Degeneration

edited by

Sankarathi Balaiya

submission deadline 19 Mar 2026 | Viewed by 82 | Submission Open

Keywords: macular degeneration; RPE; sirtuin; HDAC; oxidative stress; antioxidant; drusen; lipofuscin

Primary and Continued Cell Cultures

edited by

Xuefeng Liu

submission deadline 20 Mar 2026 | 5 articles | Viewed by 52137 | Submission Open

Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery

(This special issue belongs to the Section Cell Methods)

Organoids as an Experimental Tool

edited by

Ralf Weiskirchen

Leo A. Van Grunsven

and Anjali A. J. Roeth

submission deadline 20 Mar 2026 | 10 articles | Viewed by 39377 | Submission Open

Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids

(This special issue belongs to the Section Tissues and Organs)

The Role of Cellular Senescence in Health, Disease, and Aging

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | 10 articles | Viewed by 31781 | Submission Open

Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach

(This special issue belongs to the Section Cellular Aging)

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 20 Mar 2026 | 8 articles | Viewed by 31118 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cellular Neuroscience)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 20 Mar 2026 | 5 articles | Viewed by 28296 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells

edited by

Karuppusamy Shanmugapriya

submission deadline 20 Mar 2026 | 8 articles | Viewed by 25226 | Submission Open

Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment

(This special issue belongs to the Section Cell Methods)

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 20 Mar 2026 | 2 articles | Viewed by 18018 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances and Breakthroughs in Stem Cell Research

edited by

Alexander E. Kalyuzhny

and

Hemant Kumar Mishra

submission deadline 20 Mar 2026 | 5 articles | Viewed by 16242 | Submission Open

Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell

(This special issue belongs to the Section Stem Cells)

New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 20 Mar 2026 | 4 articles | Viewed by 12433 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Mar 2026 | 5 articles | Viewed by 10356 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5295 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy

edited by

Xin Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4755 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies

(This special issue belongs to the Section Cell Microenvironment)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2732 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2475 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

Targeting Cellular Microenvironment in Aging and Disease

edited by

Alexander Dityatev

and Egor Dzyubenko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1973 | Submission Open

Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM

(This special issue belongs to the Section Cellular Aging)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1915 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Cell Biology: The State of the Art and Perspectives in Japan 2025

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | Viewed by 864 | Submission Open

Keywords: cell biology; physiology; molecular biology

Cancer Cell Signaling, Autophagy and Tumorigenesis

edited by Debanjan Bhattacharya

submission deadline 20 Mar 2026 | 1 articles | Viewed by 549 | Submission Open

Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway

Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities

edited by

Renat Shaykhiev

, Bradley W. Richmond and

Umadevi Sajjan

submission deadline 20 Mar 2026 | Viewed by 225 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms of Neurotoxicity

edited by

Anna Andrioli

Idris Azeez

, Tiziana Cotrufo and

Olumayowa Igado

submission deadline 20 Mar 2026 | Viewed by 223 | Submission Open

Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 20 Mar 2026 | Viewed by 214 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

Novel Insights into Endothelial Cells in Vascular Disease

edited by

LI Zhang

submission deadline 20 Mar 2026 | Viewed by 140 | Submission Open

Keywords: endothelial cells; vascular diseases; vascular signaling

Novel Immunotherapies for Diffuse Large B-Cell Lymphoma

edited by

Waseem Lone

submission deadline 20 Mar 2026 | Viewed by 114 | Submission Open

Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody– drug conjugates; tumor microenvironment; biomarkers; translational research

Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease

edited by

Roger Schneiter

and Museer Ahmad Lone

submission deadline 25 Mar 2026 | 3 articles | Viewed by 6684 | Submission Open

Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation

(This special issue belongs to the Section Cellular Biophysics)

The Silent Regulators: Non-Coding RNAs in Cell Function and Disease

edited by

Christiane Branlant

and

Mirolyuba Simeonova Ilieva

submission deadline 25 Mar 2026 | 4 articles | Viewed by 3984 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Ischemic Heart Disease: From Cellular Level to Clinical Approaches

edited by

Stefan A. Juričić

and

Milan R. Dobrić

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1663 | Submission Open

Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy

Gene Editing Therapies for Hereditary Diseases

edited by

Jacques P. Tremblay

submission deadline 25 Mar 2026 | Viewed by 298 | Submission Open

Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases

(This special issue belongs to the Section Cell and Gene Therapy)

Mitochondria: Multifaceted Regulators of Cell Death

edited by Rasa Banienė and Sonata Trumbeckaite

submission deadline 25 Mar 2026 | Viewed by 183 | Submission Open

Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer

Cell and Molecular Mechanisms of Bacterial Meningitis

edited by

Lars Ove Brandenburg

submission deadline 25 Mar 2026 | Viewed by 175 | Submission Open

Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier

From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms

edited by

Ines Schoberleitner

and

Salvatore Fusco

submission deadline 25 Mar 2026 | Viewed by 172 | Submission Open

Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 25 Mar 2026 | Viewed by 169 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration

edited by

Zhaoyu Li

submission deadline 25 Mar 2026 | Viewed by 149 | Submission Open

Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control

Molecular Mechanisms of Trophoblast Differentiation

edited by Milica Jovanović Krivokuća and

Jianjun Wei

submission deadline 25 Mar 2026 | Viewed by 144 | Submission Open

Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation

Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Mar 2026 | 1 articles | Viewed by 2927 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Mar 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Neuroimaging of Cerebrovascular Diseases

edited by Dragan Stojanov

submission deadline 30 Mar 2026 | Viewed by 219 | Submission Open

Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI

Novel Insights into Cancer Immune Responsiveness

edited by

Luigi Racioppi

and

Tanmoy Mondal

submission deadline 30 Mar 2026 | 1 articles | Viewed by 201 | Submission Open

Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines

Mechanisms of miRNA Metabolism and Extracellular Transport

edited by

Suvendra N Bhattacharyya

submission deadline 30 Mar 2026 | Viewed by 198 | Submission Open

Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and