Pathophysiological Mechanism of Neurodevelopmental Disorders

Dear Colleagues,

Many genetic causes of neurodevelopmental disorders have been elucidated during the last two decades because of technological advancements in next-generation DNA sequencing. However, the elucidation of the molecular mechanisms of the pathophysiology of these diseases has not advanced at a similar pace, since these studies require multiple interdisciplinary experiments that, by nature, are low throughput. The aim of this issue is to highlight the recent advances in the identification of the molecular basis of neurodevelopmental diseases as well as elucidating the pathophysiological basis of these disorders. In this issue, we hope to address a wide range of neurodevelopmental disorders including brain malformations, ASD, ADHD, intellectual disabilities, and epilepsies. This Special Issue will feature various achievements in this rapidly expanding field of neurodevelopmental research by bringing together new knowledge on molecular cell biology, genetics, and animal studies, and present the state of the art in this research field.

We invite you to contribute original research articles or reviews on all aspects related to the theme of the “Pathophysiological Mechanisms of Neurodevelopmental Disorders”. We hope to cover functional insights into these mechanisms from molecular to cellular, tissue and animal model perspectives, and to include potential therapeutic strategies.

We look forward to your contributions.

Dr. Koh-ichi Nagata
Prof. Dr. Orly Reiner
Guest Editors

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