Inflammation and Atherosclerosis

Dear Colleagues,

Atherosclerosis is a chronic disease of large arteries. Although age and low density lipoprotein cholesterol (LDL-C) are the most important risk factors, they do not fully explain the atherosclerosis risk or the incidence of major adverse cardiovascular events (MACE). In fact, even after accounting for all Framingham risk factors, at least 50% of the risk remains unexplained. Much of this residual risk is thought to be inflammatory. The recent CANTOS trial has shown that blocking the inflammatory cytokine IL-1β with the monoclonal antibody canakinumab reduces MACE incidence in patients with high levels of the inflammatory biomarker C-reactive protein (CRP). The inflammation component of atherosclerosis involves both the innate and the adaptive immune system. Many inflammation and immune molecules are significantly associated with MACE in genome-wide association studies (GWAS). This Special Issue encompasses contributions from leading researchers in the areas of inflammatory molecules, immune cells, and genetic risk scores.

Prof. Dr. Klaus Ley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.