Generation of Hematopoietic Stem/Progenitor Cells from Pluripotent Stem Cells for Cellular Therapy

Dear Colleagues,

With Yamanaka’s landmark reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) in 2006, the appealing concept of generating iPSCs from an individual patient, correcting the genetic defect and differentiating the disease-free iPSCs into a theoretically infinite supply of transplantable autologous Hematopoietic Stem/Progenitor Cells (HSPCs) arose. However, despite recent promising reports, efficient derivation of functional HSPCs with a robust capability for definitive in vivo engraftment and multilineage potential remains challenging. Therefore, clinically feasible strategies to advance the current state of de novo HSPC generation are needed.  

This Special Issue solicits original research manuscripts and review articles on topics related to the generation of HSPCs from pluripotent stem cells (PSCs)—including, but not limited to, developmental hematopoiesis, strategies for HSPC derivation (e.g., directed differentiation, conversion), characterization of PSC-derived hematopoietic cells (e.g., transcriptome, epigenome), hematopoietic disease modelling, genetic correction/editing and differentiation of disease-specific PSCs, etc. 

Dr. Andre Larochelle
Guest Editor

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