Molecular Mechanisms of Cell Death in Gastrointestinal Disease

Dear Colleagues,

Cell death is a significant homeostatic factor, mediating the removal of damaged cells, organelles, and proteins. Many studies have focused on the process of cell death, mainly on the activators of apoptosis, and their strictly associated and interacting proteins. However, cells have several options other than apoptosis. Cell death mechanisms include intrinsic apoptosis, extrinsic apoptosis, cellular senescence, mitochondrial permeability transition (MPT)-driven necrosis, NETotic cell death, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, lysosome-dependent cell death, autophagy, immunogenic cell death, and mitotic catastrophe. In gastrointestinal tract, cell death plays a key role in development, tissue homeostasis, inflammation, immunity, and multiple pathophysiological conditions. The molecular mechanisms of cell death in gastrointestinal disease have not been fully elucidated.

This Special Issue will aim to cover novel research exploring all molecular mechanisms of cell death in gastrointestinal disease, including cancer, immune disease and infectious disease. Additionally, this Special Issue will include studies that highlight the innovative cell death-based drug targets and the associated predictive biomarkers. Original research articles, reviews are welcome. 

Dr. Grazia Serino
Guest Editor

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