Innate Immune System in Immune-Mediated Inflammatory Diseases (IMIDs)

Dear Colleagues,

Immune-mediated inflammatory diseases (IMIDs) are a diverse group of disorders characterized by the dysregulation of immune response, which results in chronic inflammation in different tissues and systems. Among these, there are pathologies directly related to an aberrant immune response, such as rheumatoid arthritis, inflammatory bowel disease, and asthma. However, IMIDs include other conditions in which the immune system is not the primary cause of the disease—e.g., cancer or infectious diseases.

Typically, the adaptive immune system has been considered the most relevant player in the development of many IMIDs. However, at present it is generally accepted that the innate immune system is equally important for the regulation and maintenance of tissue homeostasis. In fact, alterations in the mechanisms that regulate the innate immune response are responsible for an uncontrolled and exacerbated inflammatory response in intestinal tissue, among others. For this reason, more research is needed to understand the specific role played by the innate immune system during the onset and progression of IMIDs and for the development of new therapeutic approaches for these group of malignancies.

This Special Issue will include basic and translational original articles focused on aspects of innate immune responses related to IMIDs. Potential topics include autoimmune diseases, chronic inflammatory diseases, infectious diseases, immunodeficiencies, immunoproliferative disorders, or cancer.

Dr. Javier Aranda
Dr. Samuel Pérez
Guest Editors

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