Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease

Dear Colleagues,

The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest during the last two decades. The presence of a distinctive amino-terminal module composed of a RING, B-box(es) and Coiled-coil domains was employed for the first time as a family back in 2001 and for the mining of novel, at that time unrecognized, family members. In the following years, several reports demonstrated that the shared TRIM proteins’ domain composition is associated with their involvement in the ubiquitination process. Indeed, TRIM proteins act as E3 ubiquitin ligases for the specific recognition of to-be-modified substrates. Notably, TRIM family members are implicated in many clinically relevant physiological processes and in various pathological conditions. Today, many efforts are directed toward the prospect of recognizing TRIM proteins/functions as therapeutic targets. To make this possible, it is time now to take a step forward, tackling the TRIM deep role in diverse cellular processes.

To set where we are in the field of cellular function of TRIM E3 ubiquitin ligase, we aim at collecting articles in this Special Issue of Cells, and we therefore invite your contributions, either in the form of original research articles or reviews, addressing this specific topic.

Prof. Dr. Germana Meroni
Dr. Solange Desagher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.