Cellular and Molecular Mechanisms Underlying Pain Chronicity

Dear Colleagues,

Chronic pain remains an unresolved health problem and continues to pose a challenge to preclinical and clinical science. Recently, the focus of pain research has shifted to analyses of neural circuits and their plasticity. Although there are a few forms of genetically determined pain syndromes, a majority of chronic pain forms involves molecular plasticity at the level of transcriptional, epigenetic, and post-translational regulation. This issue will be dedicated to reporting and highlighting the latest insights into cellular and molecular mechanisms of chronic pain which involve these different types of molecular plasticity and their impact on neuronal activity in nociceptive circuits and ultimately on pain perception and pain-related behaviors in preclinical and clinical settings.

Prof. Dr. Rohini Kuner
Dr. Daniela Mauceri
Dr. Manuela Simonetti
Guest Editors

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