Nuclear Receptors in Metabolic and Cardiovascular Homeostasis

Dear Colleagues,

The nuclear receptor field emerged in the mid-1980s with the cloning of glucocorticoid and other steroid hormone receptors in rapid succession. Cloning of steroid receptors not only shed light on the mechanism of physiological actions of steroid hormones (e.g., estrogen, thyroid) but also gave insight into the transcriptional mechanisms of these gene regulators. It also led to the cloning of orphan receptors resulting in the formulation of a superfamily of nuclear receptors. Over the last few decades, classical steroid receptors, and more recently orphan receptors, have emerged as critical regulators of reproductive, immune, cardiovascular, ion, and metabolic homeostasis. The advent of new technologies such as gene editing in model organisms, RNA sequencing, ChIP sequencing, and synthetic biology continue to advance the field of nuclear receptors. In this Special Issue, we invite research or review articles on nuclear-receptor-related discoveries broadly related to metabolic regulation in immune and vascular cells, as well as in adipose tissue, liver, heart, and skeletal muscle. We welcome papers describing research on cells, model organisms, as well as disease models.

Dr. Vihang A. Narkar
Guest Editor

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• nuclear receptors
• metabolism
• mitochondria
• oxidative respiration
• inflammation
• angiogenesis
• circadian regulation
• vascular diseases
• obesity
• diabetes
• atherosclerosis
• degenerative diseases