Bone Cell Function and Interplay in Physiological and Pathological Conditions

Dear Colleagues,

Bone homeostasis is a dynamic equilibrium involving many cell types, such as osteoclasts, osteoblasts, and osteocytes. Moreover, many other cell types are now recognized to be involved in bone homeostasis, including immune cells, adipocytes, and mesenchymal cells. Their interplay is crucial for bone metabolism, and uncoupling of bone cell function and differentiation leads to alteration of bone structure, such as osteoporosis, osteopetrosis, and bone marrow adiposity.

Despite the clinical relevance of bone homeostasis, there is still a need for knowledge on physiological bone cell function and interaction, as well as on signaling pathways responsible for altered bone cell function during inflammatory and degenerative diseases, especially in humans.

This Special Issue invites original research articles as well as reviews on recent advances in bone cell function, differentiation, and activation in physiologic conditions, as well as during inflammatory and degenerative diseases. We especially encourage articles focusing on human bone cells, as well as articles describing the interplay of different bone cell types. Basic studies as well as preclinical studies in all fields of bone research are welcome.

Prof. Dr. Silvia Capellino
Prof. Dr. Irene Gutiérrez-Cañas
Guest Editors

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