Recent Immune Insights into the Organ Transplant

Dear Colleagues,

Organ transplantation remains the treatment of choice for patients with end-stage organ failure. Despite major advances in organ preservation, donor–recipient matching, and immunosuppressive therapies, immune-mediated graft injury and rejection continue to limit long-term outcomes. Moreover, the increasing use of extended-criteria donors highlights the need to better understand how donor characteristics, organ quality, ischemia–reperfusion injury, and recipient conditions influence immune responses and graft function.

Recent advances offer new opportunities to characterize and therapeutically modulate these complex interactions. Extracellular vesicles, microRNAs and other non-coding RNAs, cytokines, and metabolic mediators may contribute to graft–recipient and inter-organ communication. In parallel, ex vivo organ perfusion provides a promising platform for evaluating, reconditioning, and treating donor organs before transplantation. Emerging cell-based therapies and gene- and RNA-based strategies, including gene editing and targeted molecular delivery, may further enable organ-specific immune modulation, tissue repair, and promotion of immune tolerance.

The topics of interest for publication in this Special Issue include, but are not limited to, the following: transplant immunology, extended-criteria donors, ischemia–reperfusion injury, donor and recipient factors, graft–recipient crosstalk, immune biomarkers, extracellular vesicles and microRNAs, organ perfusion and reconditioning, cell therapy, gene and RNA therapies, gene editing, and novel strategies to improve graft function and long-term transplant outcomes.

Dr. Carmen Peralta
Dr. Ruben Rabadan-Ros
Guest Editors

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