Advances in Cytochrome P450

Dear Colleagues,

Cytochrome P450 (CYP) was first discovered by Klingenberg in his seminal study of “Pigments of Rat Liver Microsomes” in 1958 where he observed an intense absorption band at the 450 nm wavelength upon addition of carbon monoxide to reduced liver microsomes. Since then, cytochrome P450 enzymes have been shown to play vital roles in the metabolism of xenobiotics (e.g., drugs, environmental toxins, and nutrients) and endogenous molecules (e.g., cholesterol, steroid hormones, and lipids) in nearly all living organisms from plants, bacteria, fungi, and protozoa all the way up to humans. In addition, CYP enzymes have been successfully targeted for the development of therapeutics, e.g., CYP51 for azole antifungals and CYP17A1 for abiraterone anticancer agent. Although much is already known about the structure, function, regulation, genetic polymorphism, substrate, and inhibitor of CYP enzymes, this is only true for a handful of clinically and pharmaceutically important human CYPs. In recent years, aided by state-of-the-art multi-omics and novel technologies, exciting advances have been made in the study of CYP enzymes, e.g., new structural, functional, regulation, pharmacological, or toxicological insights, roles in non-human species, synthetic biology, bioengineering, biosensing, and biophysics. In this Special Issue, we invite you to enrich and advance our understanding of cytochrome P450s by contributing original research articles and stimulating reviews covering any topics related to cytochrome P450 enzymes.

Prof. Dr. Michael Zhuo Wang
Guest Editor

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