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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Combination Immunotherapy for Cancer Treatment—2nd Edition

edited by

Carlos Alberto Barrero

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1414 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitor; cancer vaccine; novel cancer therapy; treatment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting the Vulnerabilities of Oncogene Activation (Second Edition)

edited by

Jack L. Arbiser

submission deadline 25 Sep 2026 | Viewed by 540 | Submission Open

Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target

(This special issue belongs to the Section Methods and Technologies Development)

Acute Myeloid Leukemia: Updates on Diagnosis and Novel Management Strategies

edited by Ana Vidović

submission deadline 25 Sep 2026 | Viewed by 359 | Submission Open

Keywords: acute myeloblastic leukemia; diagnosis; prognosis; intensive chemotherapy; target therapy; allogeneic stem cell transplantation

(This special issue belongs to the Section Clinical Research in Cancer)

Role of Iron Metabolism in Tumor Progression

edited by

Xiang Xue

submission deadline 25 Sep 2026 | Viewed by 350 | Submission Open

Keywords: iron metabolism; ferroptosis; tumor microenvironment; oxidative stress; iron chelation therapy; ferritin; transferrin receptor; cancer metabolism; redox homeostasis; therapeutic targeting

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Pathology in Cancer: From Diagnosis to Precision Medicine

edited by

Georgia Levidou

submission deadline 28 Sep 2026 | Viewed by 511 | Submission Open

Keywords: cancer biomarkers; precision medicine; histopathology; clinical pathology; diagnosis; prognostic/predictive biomarker

(This special issue belongs to the Section Cancer Pathophysiology)

Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition)

edited by

Bartosz Małkiewicz

Jakub Dobruch

and

Łukasz Nowak

submission deadline 30 Sep 2026 | 10 articles | Viewed by 21882 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 30 Sep 2026 | 13 articles | Viewed by 17541 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy for Skin Cancers

edited by

Reinhard Dummer

and Lara Valeska Maul-Duwendag

submission deadline 30 Sep 2026 | 4 articles | Viewed by 12481 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; merkel cell carcinoma; kaposi sarcoma; cutaneous angi-osarcoma; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma

edited by

Norihiro Imai

and

Dongming Liu

submission deadline 30 Sep 2026 | 5 articles | Viewed by 11556 | Submission Open

Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent

(This special issue belongs to the Section Cancer Biomarkers)

Health Economic and Policy Issues Regarding Cancer

edited by

Aviad Tur-Sinai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 9096 | Submission Open

Keywords: cancer economics; health policy; cost-effectiveness; financial toxicity; healthcare disparities; value-based oncology

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-Axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2026 | 2 articles | Viewed by 8012 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI, MR spectroscopy, perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research in Cancer)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 30 Sep 2026 | 7 articles | Viewed by 7640 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH, TERT, and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy, radiation therapy, immunotherapy, and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer

edited by

Greta Alì

and

Maria Giovanna Mastromarino

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6736 | Submission Open

Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6663 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Fertility Preservation and Hormonal Health in Oncology

edited by

Amelia Barcellini

and

Chiara Cassani

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6608 | Submission Open

Keywords: oncofertility; fertility preservation; hormonal health; cancer survivorship; reproductive oncology

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6517 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Current Issues, Innovations, and Emerging Therapies in Thoracic Surgical Oncology

edited by Inderpal S. Sarkaria and Shamus Carr

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6395 | Submission Open

Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6294 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation

edited by

Lara Edbrooke

and Chris Swain

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5758 | Submission Open

Keywords: cancer; survivorship; exercise; physical activity; implementation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer

edited by

Marta Lukaszewicz-Zajac

and

Adrianna Romanowicz

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5636 | Submission Open

Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Biomarkers of Urological Cancers

edited by

Aristotelis Bamias

Michalis Liontos

and Zisis Kratiras

submission deadline 30 Sep 2026 | 6 articles | Viewed by 5508 | Submission Open

Keywords: biomarkers; urothelial cancer; prostate cancer; renal cancer; checkpoint inhibitors; PD-L1; KIM-1; FGFR3; BRCA; HRD

(This special issue belongs to the Section Cancer Biomarkers)

Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms

edited by

Takahiro Nakajima

and

George A. Eapen

submission deadline 30 Sep 2026 | 8 articles | Viewed by 5445 | Submission Open

Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing

(This special issue belongs to the Section Cancer Therapy)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5421 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5317 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in Lung Cancer Treatment Strategies

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5293 | Submission Open

Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors; chemoimmunotherapy; target therapy; biomarkers; non-small cell lung cancer; precision medicine

(This special issue belongs to the Section Cancer Therapy)

The Cellular Ecosystem of Cancer: New Insights into Cell Biology

edited by Xiaochao Tan and

Guan-Yu Xiao

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5071 | Submission Open

Keywords: cell organelle; ER; mitochondria; lysosome; Golgi; secretion; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and

Kanae Taruno

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4505 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Brain Tumors

edited by

David S. Baskin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4475 | Submission Open

Keywords: diagnosis; biomarker; treatment; brain tumors

(This special issue belongs to the Section Clinical Research in Cancer)

Cancer Survivors: Late Effects of Cancer Therapy

edited by

Gaurav Kumar

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4251 | Submission Open

Keywords: late effects; cancer survivorship; treatment toxicity; long-term outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pre-Clinical Studies of Personalized Medicine for Cancer Research: 2nd Edition

edited by

Nuno Vale

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4081 | Submission Open

Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation

(This special issue belongs to the Section Molecular Cancer Biology)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3679 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Management of Orbital Tumors

edited by

Peerooz Saeed

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3415 | Submission Open

Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques

(This special issue belongs to the Section Clinical Research in Cancer)

Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

edited by

Sam Payabvash

and Stefan Haider

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3385 | Submission Open

Keywords: machine learning; radiomics; cancer imaging; malignancy; survival

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by

Cesare Guida

and Ida D'Onofrio

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3166 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Cancer and Melatonin: Updates on Current Findings

edited by

Rita Rezzani

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2947 | Submission Open

Keywords: cancer; melatonin; oxidative stress; inflammation; antioxidant defense

Novel Advancements in Prostate Cancer Surgery: Indications and Techniques

edited by Valerio Santarelli and

Alessandro Sciarra

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2901 | Submission Open

Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Advances in Pathogenesis and Pathology Diagnosis of Gynecologic Cancers

edited by

Wenxin Zheng

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2869 | Submission Open

Keywords: gynecologic cancers; molecular pathology; tumor pathogenesis; diagnostic biomarkers; precision medicine; endometrial carcinoma; ovarian cancer; cervical cancer; histopathology; translational research

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2824 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Trials and Translational Research in Multiple Myeloma

edited by Laszlo Varoczy

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2819 | Submission Open

Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial

(This special issue belongs to the Section Clinical Research in Cancer)

Hematologic Malignancies: Clinical Features and Prognostic Indicators

edited by Danijela Leković

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2542 | Submission Open

Keywords: leukemia; myelodysplastic syndrome; myeloproliferative neoplasms; lymphoma; multiple myeloma; diagnosis; prognosis; molecular markers; infections; survival; machine learning

(This special issue belongs to the Section Clinical Research in Cancer)

Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions

edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2342 | Submission Open

Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery

(This special issue belongs to the Section Pediatric Oncology)

miRNAs in Targeted Cancer Therapy

edited by Mustafa Özen

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2317 | Submission Open

Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in PET/CT Imaging in Cancer Management

edited by Jasna M. Mihailovic and Mihaela Raluca Mititelu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2305 | Submission Open

Keywords: PET/CT imaging; oncology; staging; restaging; treatment monitoring; recurrence detection

(This special issue belongs to the Section Methods and Technologies Development)

Targeting RNA to Improve Cancer Precision Medicine

edited by

Gabriella Misso

, Anna Grimaldi and Chiara Tammaro

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2274 | Submission Open

Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advanced Strategies for Precision Therapy in Urinary Cancers

edited by Menghuan Tang and

Zhaoqing Cong

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2268 | Submission Open

Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy

(This special issue belongs to the Section Cancer Therapy)

Screening, Early Detection and Therapeutic Advances in Gastrointestinal Cancers

edited by

Arkadeep Dhali

and

Saikat Mandal

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2112 | Submission Open

Keywords: gastrointestinal cancer; screening; advanced endoscopy; imaging platforms; circulating biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Ablation Treatment for Malignant Tumors

edited by

Madelon Dijkstra

Martijn Meijerink

and

Susan Van Der Lei

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2108 | Submission Open

Keywords: ablative therapies; thermal ablation; image-guided therapy; minimally invasive; radiofrequency ablation (RFA); microwave ablation (MWA); cryoablation; irreversible electroporation (IRE); malignant tumors; oligometastatic disease; immunotherapy combinations; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

Senescence and Cell Plasticity in Cancer Development

edited by

Eva María Verdugo-Sivianes

and Elena Aguado-Domínguez

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1987 | Submission Open

Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development

(This special issue belongs to the Section Molecular Cancer Biology)

Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives

edited by

Alba Di Leone

and

Elena Jane Mason

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1839 | Submission Open

Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship

(This special issue belongs to the Section Clinical Research in Cancer)

Cell Cycle Dysregulation in Cancers

edited by Radoslav Janostiak

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1662 | Submission Open

Keywords: cell cycle regulation; proliferation-quiescence decision; post translational regulation; quiescence maintenance; senescence escape; environmental stress adaptation; minimal residual disease; cell cycle checkpoints

(This special issue belongs to the Section Molecular Cancer Biology)

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