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Combination Immunotherapy for Cancer Treatment—2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 1336

Editor


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Guest Editor
Proteomics and Metabolomics Facility, Moulder Center for Drug Discovery Research, Temple University, Philadelphia, PA 19140, USA
Interests: cancer immunotherapy; proteomics; metabolomics; diabetes; COPD; HIV
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue represents a continuation of our previous Special Issue titled “Combination Immunotherapy for Cancer Treatment” (https://www.mdpi.com/journal/cancers/special_issues/P16946Y131).

This Special Issue will be dedicated to exploring the fascinating field of combination immunotherapy and its potential to revolutionize cancer treatment. In recent years, immunotherapy has emerged as an exciting approach in the fight against cancer, harnessing the power of the immune system to target and destroy cancer cells. However, single-agent immunotherapy has shown limitations in achieving complete and durable responses in all patients. That is where combination immunotherapy comes into play. By combining different immunotherapeutic agents, such as immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell transfer, researchers and clinicians aim to enhance the effectiveness of treatment and overcome resistance mechanisms. Original research works and review articles covering the aforementioned or any novel biologics-mediated cancer treatment or immunotherapy will be considered for this Special Issue.

Dr. Carlos Alberto Barrero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunotherapy
  • immune checkpoint inhibitor
  • cancer vaccine
  • novel cancer therapy
  • treatment

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Published Papers (1 paper)

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Review

36 pages, 2538 KB  
Review
Rational Immune Checkpoint Inhibitor-Based Combination Immunotherapy in Cancer: Mechanistic Design, Biomarker Selection, and Implications for Oncology Pharmacy
by Mathias Sanchez Machado, Sangnya A. Upadhyaya, Saipriya Gadiraju, Matthew Santhosh, John Gaba, Patrick J. Mcdonnell, Jacobo Hincapie-Echeverri and Carlos A. Barrero
Cancers 2026, 18(13), 2163; https://doi.org/10.3390/cancers18132163 - 6 Jul 2026
Viewed by 1047
Abstract
Cancer immunotherapy has reshaped oncology, yet durable benefit remains limited for many patients because antitumor responses are constrained by multiple biological and clinical barriers. A targeted narrative review was conducted using peer-reviewed literature indexed in PubMed, Scopus, and Web of Science from January [...] Read more.
Cancer immunotherapy has reshaped oncology, yet durable benefit remains limited for many patients because antitumor responses are constrained by multiple biological and clinical barriers. A targeted narrative review was conducted using peer-reviewed literature indexed in PubMed, Scopus, and Web of Science from January 2020 to April 2026, with additional landmark studies from earlier years included for essential mechanistic context. Priority was given to clinical, translational, and high-impact review articles examining combination strategies built on immune checkpoint blockade and related immune platforms. The evidence was synthesized by the main barriers each strategy aims to overcome, including poor immune priming, immune exclusion, immunosuppressive tumor microenvironments, adaptive resistance, and limited treatment durability. Across recent studies, combination immunotherapy is increasingly moving away from empiric regimen construction toward biologically rational approaches that integrate checkpoint blockade with chemotherapy, radiotherapy, antiangiogenic therapy, targeted agents, antibody–drug conjugates, bispecific antibodies, vaccines, and cellular platforms. Increasing emphasis has also been placed on integrated biomarkers that combine tumor-intrinsic, immune, spatial, and dynamic features to improve patient selection. At the same time, growing regimen complexity continues to raise challenges related to overlapping toxicity, sequencing, polypharmacy, and multidisciplinary implementation. Overall, the field is evolving toward mechanism-matched, biomarker-guided, and clinically manageable strategies that may broaden and refine the benefit of cancer immunotherapy. Full article
(This article belongs to the Special Issue Combination Immunotherapy for Cancer Treatment—2nd Edition)
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