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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition

edited by

Andrew Stephens

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10229 | Submission Open

Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion

(This special issue belongs to the Section Cancer Biomarkers)

Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets

edited by

Annapina Russo

Giulia Russo

and

Annalisa Pecoraro

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10225 | Submission Open

Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction

(This special issue belongs to the Section Cancer Biomarkers)

Radiomics in Cancer

edited by Isabelle M. Germano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10095 | Submission Open

Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care

(This special issue belongs to the Section Cancer Therapy)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9515 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Technological Development for Advances in Cancer Research and Precision Oncology

edited by

Nelson Yee

Ilias Georgakopoulos-Soares

and Fenglong Ma

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9429 | Submission Open

Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics

(This special issue belongs to the Section Molecular Cancer Biology)

Immunotherapy in Non-Small Cell Lung Cancers

edited by Marco Russano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8899 | Submission Open

Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advancements in Head and Neck Cancer Surgery

edited by

Carlos M. Chiesa-Estomba

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8169 | Submission Open

Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging

(This special issue belongs to the Section Clinical Research of Cancer)

Ovarian Cancer Stem Cells and Tumor Microenvironment

edited by

Carrie House

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8034 | Submission Open

Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts

(This special issue belongs to the Section Tumor Microenvironment)

Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics

edited by

Athanasios G. Papavassiliou

and

Le Zhang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8018 | Submission Open

Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications

(This special issue belongs to the Section Cancer Therapy)

Precision Oncology for Rare Skin Cancers

edited by Gino K. In and Aparna Nallagangula

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7538 | Submission Open

Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition

edited by

Andrzej Deptała

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7495 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiation Therapy for Head and Neck Cancer

edited by

Vassilis Kouloulias

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7475 | Submission Open

Keywords: adaptive radiotherapy ; hyper- and hypo-fractionated radiotherapy ; artificial intelligence in radiotherapy for head and neck cancer ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques ; protons and heavy ions for radiotherapy ; re-irradiation ; nanoparticles plus radiotherapy ; hyperthermia plus radiotherapy ; radiotherapy plus immunotherapy ; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Cost-Effectiveness Studies in Cancers

edited by

Ippazio Cosimo Antonazzo

Paolo Angelo Cortesi

and

Pietro Ferrara

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7465 | Submission Open

Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Recent Advances in Non-muscle Invasive Bladder Cancer

edited by Paul L. Crispen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7454 | Submission Open

Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

AI-Based Applications in Cancers

edited by

Xia Jiang

submission deadline 31 Dec 2025 | 9 articles | Viewed by 7332 | Submission Open

Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer

(This special issue belongs to the Section Cancer Informatics and Big Data)

Advances in Surgical Treatment of Urinary Tumors

edited by Pierre I. Karakiewicz and

Simone Morra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6962 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology

(This special issue belongs to the Section Cancer Therapy)

Radiosurgery for Brain Tumors

edited by Anna Petoukhova

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6842 | Submission Open

Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)

(This special issue belongs to the Section Cancer Therapy)

Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours

edited by

Magdalena Görtz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6691 | Submission Open

Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer

edited by

Luca Viganò

and Pietro Majno

submission deadline 31 Dec 2025 | 1 articles | Viewed by 6643 | Submission Open

Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence-Assisted Radiomics in Cancer

edited by

Seong K. Mun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6609 | Submission Open

Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Treatment of Hepatocellular Carcinoma

edited by

Wei-Chen Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6497 | Submission Open

Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research

(This special issue belongs to the Section Clinical Research of Cancer)

Enhancing Cancer Treatments through Fluorescence-Guided Surgery

edited by Ibrahim Khot and Yazan Sulaiman Khaled

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6493 | Submission Open

Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Feature Review for Cancer Therapy: 2nd Edition

edited by

Robert Kleszcz

and

Jarosław Paluszczak

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6191 | Submission Open

Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5960 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5926 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5708 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications

edited by

Hisham Bahmad

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5625 | Submission Open

Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Clear Cell Renal Cell Carcinoma 2024–2025

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5614 | Submission Open

Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Feature Papers in Section “Cancer Informatics and Big Data”

edited by

Jason Roszik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5267 | Submission Open

Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5165 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in the Management of Central Nervous System (CNS) Tumors

edited by

Alessia Pellerino

, Francesco Bruno and

Teresa Somma

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4985 | Submission Open

Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors

(This special issue belongs to the Section Cancer Therapy)

Molecular Mechanisms in Bone and Soft Tissue Sarcomas

edited by

Alexander L. Lazarides

and Zachary D.C. Burke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4651 | Submission Open

Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era

edited by Talha Badar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4485 | Submission Open

Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4322 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Advances in Ovarian Cancer Treatment: Past, Present and Future

edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4264 | Submission Open

Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4079 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies

edited by Akshay Jatin Patel and Marcus Taylor

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3938 | Submission Open

Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy

(This special issue belongs to the Section Methods and Technologies Development)

Endometrial Cancer—from Diagnosis to Management

edited by Mingxin Shi and

Xiang Zhao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3794 | Submission Open

Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention

(This special issue belongs to the Section Cancer Therapy)

Innovations in Addressing Disparities in Cancer

edited by

Rajesh Singh

and

Shailesh Singh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3591 | Submission Open

Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3442 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Targets for Metastatic Lung Cancer

edited by

Andrea De Giglio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3355 | Submission Open

Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation

(This special issue belongs to the Section Cancer Therapy)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3352 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3247 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3097 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Chemotherapy and Immunotherapy of Lung Cancer

edited by

Sonia Vallet

and Klaus Hackner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3094 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Palliative Care and Pain Management in Cancer

edited by María Fernández-Gonzáles and Moira O'Connor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3093 | Submission Open

Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2768 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2719 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Peritoneal Carcinomatosis

edited by Neda Dadgar and Patrick L. Wagner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2566 | Submission Open

Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid

(This special issue belongs to the Section Clinical Research of Cancer)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2435 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 51-100 on page 2 of 25.

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