Radiomics in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 1 August 2025 | Viewed by 1016

Special Issue Editor


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Guest Editor
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY, USA
Interests: machine learning; radiomics; brain cancer; neurosurgery; neuro

Special Issue Information

Dear Colleagues,

Radiomics is an innovative and rapidly expanding field that combines medical imaging, computer science, and data analysis to improve cancer care. By extracting detailed quantitative data from medical images, radiomics provides unique insights that can guide personalized treatment plans. This approach requires collaboration among radiologists, imaging scientists, and data scientists, each bringing a specialized expertise to navigate the complex workflow. The radiomics process typically follows a structured sequence: tumor segmentation, where the tumor is outlined; image preprocessing, which standardizes images for analysis; feature extraction, which identifies relevant characteristics; and finally, model development and validation, ensuring that results are reliable. Each step is essential to produce accurate, actionable insights.

One of the most promising aspects of radiomics is its potential to transform the diagnosis, staging, and management of cancer. Through advanced imaging analysis, radiomics can help in diagnosing and precisely staging different cancer types, enabling clinicians to make well-informed decisions. It can also predict the likelihood of metastasis, allowing doctors to consider more targeted treatments, and estimate patient survival, which can help with treatment planning and patient counseling. Additionally, radiomics offers a way to evaluate the effectiveness of therapies over time, potentially providing early indications of treatment response. These capabilities have significant implications for improving patient outcomes and tailoring interventions to individual patients’ needs.

Despite the enthusiasm surrounding radiomics, there are challenges and limitations that must be addressed to fully integrate it into routine clinical practice. Physicians and researchers need to be aware of potential pitfalls, such as variability in imaging techniques, data quality, and the reproducibility of results, which can impact the reliability of radiomic models. There is also the need for rigorous validation across diverse patient populations to ensure that models are generalizable. This Special Issue aims to explore these current limitations in radiomics for cancer, assess the state of the art, and discuss future directions for advancing the field, with the ultimate goal of refining and expanding radiomics to enhance cancer therapies and patient care.

Dr. Isabelle M. Germano
Guest Editor

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Keywords

  • radiomic
  • medical imaging
  • personalized treatment
  • diagnosis
  • staging
  • management
  • targeted treatment
  • patient outcome
  • clinical practice
  • cancer therapies
  • patient care

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Published Papers (2 papers)

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Review

14 pages, 721 KiB  
Review
Role of Artificial Intelligence in Musculoskeletal Interventions
by Anuja Dubey, Hasaam Uldin, Zeeshan Khan, Hiten Panchal, Karthikeyan P. Iyengar and Rajesh Botchu
Cancers 2025, 17(10), 1615; https://doi.org/10.3390/cancers17101615 - 10 May 2025
Viewed by 437
Abstract
Artificial intelligence (AI) has rapidly emerged as a transformative force in musculoskeletal imaging and interventional radiology. This article explores how AI-based methods—including machine learning (ML) and deep learning (DL)—streamline diagnostic processes, guide interventions, and improve patient outcomes. Key applications discussed include ultrasound-guided procedures [...] Read more.
Artificial intelligence (AI) has rapidly emerged as a transformative force in musculoskeletal imaging and interventional radiology. This article explores how AI-based methods—including machine learning (ML) and deep learning (DL)—streamline diagnostic processes, guide interventions, and improve patient outcomes. Key applications discussed include ultrasound-guided procedures for joints, nerves, and tumor-targeted interventions, along with CT-guided biopsies and ablations, and fluoroscopy-guided facet joint and nerve block injections. AI-powered segmentation algorithms, real-time feedback systems, and dose-optimization protocols collectively enable greater precision, operator consistency, and patient safety. In rehabilitation, AI-driven wearables and predictive models facilitate personalized exercise programs that can accelerate recovery and enhance long-term function. While challenges persist—such as data standardization, regulatory hurdles, and clinical adoption—ongoing interdisciplinary collaboration, federated learning models, and the integration of genomic and environmental data hold promise for expanding AI’s capabilities. As personalized medicine continues to advance, AI is poised to refine risk stratification, reduce radiation exposure, and support minimally invasive, patient-specific interventions, ultimately reshaping musculoskeletal care from early detection and diagnosis to individualized treatment and rehabilitation. Full article
(This article belongs to the Special Issue Radiomics in Cancer)
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18 pages, 1647 KiB  
Review
The Evolving Landscape of Radiomics in Gliomas: Insights into Diagnosis, Prognosis, and Research Trends
by Mehek Dedhia and Isabelle M. Germano
Cancers 2025, 17(9), 1582; https://doi.org/10.3390/cancers17091582 - 6 May 2025
Viewed by 367
Abstract
Gliomas are the most prevalent and aggressive form of primary brain tumors. The clinical challenge in managing patients with this disease revolves around the difficulty of diagnosis, both at onset and during treatment, and the scarcity of prognostic outcome indicators. Radiomics involves the [...] Read more.
Gliomas are the most prevalent and aggressive form of primary brain tumors. The clinical challenge in managing patients with this disease revolves around the difficulty of diagnosis, both at onset and during treatment, and the scarcity of prognostic outcome indicators. Radiomics involves the extraction of quantitative features from medical images with the help of artificial intelligence, positioning it as a promising tool to be integrated into the care of glioma patients. Using data from 52 studies and 12,482 patients over two years, this review explores how radiomics can enhance the initial diagnosis of gliomas, especially helping to differentiate treatment stages that may be difficult for the human eye to do otherwise. Radiomics has also been able to identify patient-specific tumor molecular signatures for targeted treatments without the need for invasive surgical biopsy. Such an approach could lead to earlier interventions and more precise individualized therapies that are tailored to each patient. Additionally, it could be integrated into clinical practice to improve longitudinal diagnosis during treatment and predict tumor recurrence. Finally, radiomics has the potential to predict clinical outcomes, helping both patients and providers set realistic expectations. While this field is continuously evolving, future research should conduct such studies in larger, multi-institutional cohorts to enhance generalizability and applicability in clinical practice and focus on combining radiomics with other modalities to improve its predictive accuracy and clinical utility. Full article
(This article belongs to the Special Issue Radiomics in Cancer)
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