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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 30 Jun 2026 | 2 articles | Viewed by 518 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration

edited by

Ken Kudura

and Robert Förster

submission deadline 30 Jun 2026 | 1 articles | Viewed by 481 | Submission Open

Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Perspectives in Lung Cancer: From Technique to Outcome

edited by Takahiro Homma and Hyun Koo Kim

submission deadline 30 Jun 2026 | Viewed by 424 | Submission Open

Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery

(This special issue belongs to the Section Cancer Therapy)

Recent Updates on Treatment of Uveal Melanoma

edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr

submission deadline 30 Jun 2026 | Viewed by 418 | Submission Open

Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research

(This special issue belongs to the Section Cancer Therapy)

Updates on Anti-Cancer Drug Research

edited by

Ana Luísa De Sousa-Coelho

and Mónica Fernandes

submission deadline 30 Jun 2026 | 1 articles | Viewed by 385 | Submission Open

Keywords: anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding RNAs; multi-omics data

(This special issue belongs to the Section Cancer Drug Development)

Immunotherapy Approaches in Breast Cancer Treatment (2nd Edition)

edited by Yi Huang and

Bing Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 374 | Submission Open

Keywords: breast cancer progression; immunotherapy; combination therapy; drug discovery; antitumor immunity; tumor immune microenvironment; biomarkers and clinical trials

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma

edited by

Vera Ulrike Bacher

and

Ashwini K. Yenamandra

submission deadline 30 Jun 2026 | Viewed by 368 | Submission Open

Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment

(This special issue belongs to the Section Cancer Therapy)

Research and Treatment of Hepatocellular Carcinoma

edited by Chung Cheung Thomas Yau

submission deadline 30 Jun 2026 | 1 articles | Viewed by 359 | Submission Open

Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments

(This special issue belongs to the Section Cancer Therapy)

Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically

edited by

Vaishali Aggarwal

and Alok Kumar

submission deadline 30 Jun 2026 | Viewed by 343 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Research Challenges in Adolescent and Young Adult Cancer

edited by

Lorna A. Fern

and Jeremy Lewin

submission deadline 30 Jun 2026 | Viewed by 327 | Submission Open

Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers

(This special issue belongs to the Section Pediatric Oncology)

Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges

edited by Sajid Khan

submission deadline 30 Jun 2026 | Viewed by 320 | Submission Open

Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery

(This special issue belongs to the Section Cancer Therapy)

Proton and Light Ion Therapy for Cancer

edited by Oliver Jäkel

submission deadline 30 Jun 2026 | Viewed by 315 | Submission Open

Keywords: novel beam delivery concepts; image guidance; adaptive therapy; in vivo monitoring; radiobiological studies with protons and light ions; clinical studies; outcome reports

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities and Health Equity: Challenges, Insights, and Transformative Strategies

edited by

Mandi Pratt-Chapman

and Jane Ussher

submission deadline 30 Jun 2026 | Viewed by 311 | Submission Open

Keywords: scientific censorship; terminated grants; identity politics and health; LGBTQI+ cancer health equity; LGBTQI+ cancer survivorship and care

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Neoadjuvant Therapy for Urologic Cancer

edited by Carlo Messina

submission deadline 30 Jun 2026 | 1 articles | Viewed by 310 | Submission Open

Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates

(This special issue belongs to the Section Cancer Therapy)

Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy

edited by

Luca Tamagnone

and Roberta Mastrantonio

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism

(This special issue belongs to the Section Tumor Microenvironment)

Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer

edited by Tim Strate and

Jonas Herzberg

submission deadline 30 Jun 2026 | Viewed by 287 | Submission Open

Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC

(This special issue belongs to the Section Cancer Therapy)

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 30 Jun 2026 | Viewed by 253 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)

edited by

Francis Levi

Pasquale F. Innominato

and Esra Tasali

submission deadline 30 Jun 2026 | Viewed by 223 | Submission Open

Keywords: drug development and chronotherapy; chemotherapy; immunotherapy; targeted agents; radiotherapy; surgery; circadian host or tumor biomarkers; electronic patient-reported outcomes; circadian rhythms and sleep; sex- and age specificities; clinical trial designs; mathematical models and artificial intelligence; digital healthcare; telemedicine and logistics

(This special issue belongs to the Section Cancer Therapy)

The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment

edited by

Maria Georgiadou

Eirini Velliou

and

Eugenia Roupakia

submission deadline 30 Jun 2026 | Viewed by 210 | Submission Open

Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits

edited by

Alessandro Loglio

submission deadline 30 Jun 2026 | Viewed by 171 | Submission Open

Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition

(This special issue belongs to the Section Cancer Therapy)

Tumor Microenvironment of Thyroid Carcinoma

edited by

Juan Carlos Jaume

submission deadline 30 Jun 2026 | Viewed by 161 | Submission Open

Keywords: thyroid cancer; tumor immune microenvironment (TIME); double-negative T cells (DN T cells); tumor-associated macrophages (TAMs)

(This special issue belongs to the Section Tumor Microenvironment)

Emerging Therapies for Germ Cell Tumors

edited by

Ratnakar Singh

and Krinio Giannikou

submission deadline 30 Jun 2026 | Viewed by 158 | Submission Open

Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

A New Road for Cancer Drug Discovery

edited by

Navnath S. Gavande

and

Yubin Ge

submission deadline 30 Jun 2026 | Viewed by 154 | Submission Open

Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy

(This special issue belongs to the Section Cancer Drug Development)

Human Carcinogens—New Insights from Occupational Exposure

edited by

Enrico Oddone

and

Roberta Pernetti

submission deadline 30 Jun 2026 | Viewed by 150 | Submission Open

Keywords: occupational carcinogens; chemical exposure; cancer prevention; artificial intelligence (AI); workplace health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Basic and Translational Science in Ocular Oncology

edited by Anthony B. Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 30 Jun 2026 | Viewed by 145 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Cancer Pathophysiology)

Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy

edited by

Maria Francesca Baietti

submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open

Keywords: arginine; cancer; therapy; immunotherapy; metabolism

(This special issue belongs to the Section Cancer Drug Development)

Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis

edited by

Nan Hu

submission deadline 30 Jun 2026 | Viewed by 140 | Submission Open

Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Myeloma and Immunology

edited by

Cristina João

submission deadline 30 Jun 2026 | Viewed by 138 | Submission Open

Keywords: multiple myeloma; tumor immunology; immune microenvironment; immunotherapy; CAR-T cells; immune evasion; immune profiling

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by

Nicolas Nassar

submission deadline 30 Jun 2026 | Viewed by 137 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology

edited by

Ilyas Sahin

submission deadline 30 Jun 2026 | Viewed by 134 | Submission Open

Keywords: gastric cancer; esophageal cancer; immunotherapy targeted therapy; radiation therapy; surgical oncology; precision oncology; molecular biomarkers; multimodal treatment

(This special issue belongs to the Section Cancer Therapy)

Clinical Application of Proton Therapy and Advanced Radiotherapy in Gynecological Cancer

edited by Amy Tien Yee Chang and

Bin Yang

submission deadline 30 Jun 2026 | Viewed by 133 | Submission Open

Keywords: proton therapy; cervical cancer; endometrial cancer; vaginal cancer; MR-guided radiotherapy; MR-guided brachytherapy; stereotactic body radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 30 Jun 2026 | Viewed by 131 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Pharmacokinetics in Cancer Treatment

edited by Jing Li

submission deadline 30 Jun 2026 | Viewed by 129 | Submission Open

Keywords: pharmacokinetics (PK); pharmacodynamics (PD); population PK/PD modeling; PBPK modeling; clinical pharmacology; personalized oncology; cancer treatment; pharmacogenetics; molecular pharmacology

(This special issue belongs to the Section Cancer Drug Development)

Advances in Clinical Treatment of Pancreatic Cancers

edited by

Alberto Brolese

submission deadline 30 Jun 2026 | Viewed by 123 | Submission Open

Keywords: pancreatic cancer; PDAC; neoadjuvant chemotherapy; neuroendocrine tumors; pNET; pancreatic cystic disease; IPMN; pancreatic oligometastases

(This special issue belongs to the Section Clinical Research of Cancer)

Contemporary Thoracic Cancer Surgery: Technology and Innovation

edited by

Yoshikane Yamauchi

submission deadline 30 Jun 2026 | Viewed by 118 | Submission Open

Keywords: thoracic cancer surgery; robotic-assisted thoracic oncology procedures; video-assisted thoracoscopic surgery for thoracic malignancies; thoracic neoplasms; minimally invasive surgery in cancer treatment; surgical outcomes; lung cancer surgery; surgical innovation in thoracic oncology

(This special issue belongs to the Section Methods and Technologies Development)

Nanocarriers in Cancer Therapy

edited by

Wenyi Gu

submission deadline 30 Jun 2026 | Viewed by 112 | Submission Open

Keywords: nanoparticles; cancer therapy; anticancer drug delivery

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Mechanisms of Cancer Progression and Metastasis

edited by

Babak Behnam

submission deadline 30 Jun 2026 | Viewed by 108 | Submission Open

Keywords: metastasis; molecular mechanisms; tumor microenvironment (TME); epithelial-to-mesenchymal transition (EMT); cancer stem cell; therapeutic strategies; immune evasion

(This special issue belongs to the Section Cancer Metastasis)

Long-Read Sequencing in Cancer (2nd Edition)

edited by

Luca Ermini

and Patrick Driguez

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: long-read sequencing; cancer genetics; genomics; transcriptomics; methylomics; cancer research

(This special issue belongs to the Section Molecular Cancer Biology)

Prostate Cancer Pathology and Grade

edited by

Stefano Marletta

and

Giuseppe Fanelli

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: prostate cancer; Gleason grading; molecular pathology; artificial intelligence; digital pathology; multimodal algorithms

(This special issue belongs to the Section Cancer Pathophysiology)

Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution

edited by

Angeliki Magklara

and

Spyros Foutadakis

submission deadline 30 Jun 2026 | Viewed by 103 | Submission Open

Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Cancer Biology)

CDK4/6 Inhibitors in Cancer: Efficacy, Resistance, and Combination Approaches

edited by

Boshi Wang

submission deadline 30 Jun 2026 | Viewed by 102 | Submission Open

Keywords: CDK4/6 inhibitors; palbociclib; abemaciclib; ribociclib; cancer; senescence; combinatorial therapy; prognosis; molecular mechanisms

(This special issue belongs to the Section Cancer Therapy)

Ras-Directed Therapies: A Revolution

edited by

Naiara Perurena

submission deadline 30 Jun 2026 | Viewed by 90 | Submission Open

Keywords: Ras-driven cancers; Ras inhibitors; Ras degraders; Ras signaling; mechanisms of resistance; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Radiation Therapy for Metastatic Cancer

edited by Johnny Kao

submission deadline 30 Jun 2026 | Viewed by 87 | Submission Open

Keywords: metastasis; radiation therapy; tumor agnostic; oligometastases; survivorship; combined modality therapy

(This special issue belongs to the Section Cancer Therapy)

Magnetic Resonance in Cancer Research (2nd Edition)

edited by Qiuhong He and Marie-France Vidaver

submission deadline 30 Jun 2026 | Viewed by 83 | Submission Open

Keywords: magnetic resonance; cancer; MRI; MRS; MRSI; NMR; DWI; MR; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Progress in Targeted Nanotherapeutic Delivery Systems for Cancer Precision Medicine

edited by

Linlin Zhang

and Dhananjay Suresh

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: cancer therapy; drug delivery; tumor targeting; nanotechnology; precision medicine; immunotherapy; new approach methodologies (NAMs)

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Opportunities in Radiation Oncology: AI, Radiomics, and Particle Therapy Breakthroughs

edited by

Antonio Pontoriero

and

Sara Lillo

submission deadline 30 Jun 2026 | Viewed by 79 | Submission Open

Keywords: radiotherapy; artificial intelligence; radiomics; machine learning; adaptive planning; proton therapy; hadron therapy; precision oncology; particle radiotherapy; clinical outcomes

Immunotherapy for Acute Lymphoblastic Leukemia: Novel Strategies and Clinical Perspectives

edited by Paola Minetto and

Francesco Grimaldi

submission deadline 30 Jun 2026 | Viewed by 75 | Submission Open

Keywords: immunotherapy; CAR T-cell therapy; bispecific antibodies; antibody– drug conjugates; treatment resistance; clinical perspectives; clinical trial in ALL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Symptom Burden in Cancer: Assessment and Management: 2nd Edition

edited by Sam M. Salek,

Esther Natalie Oliva

and Tatyana Ionova

submission deadline 30 Jun 2026 | Viewed by 69 | Submission Open

Keywords: symptom burden; patient-reported outcomes; symptom assessment; symptom management; cancer survivorship; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Fertility and Pregnancy in Cancer

edited by

Bettina Böttcher

submission deadline 30 Jun 2026 | Viewed by 64 | Submission Open

Keywords: cancer; gonadotoxic treatment; pregnancy; offspring; long term survivorship; fertility preservation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Living with Cancer as a Chronic Disease: Quality of Life and Supportive Care

edited by

Paolo Cotogni

submission deadline 30 Jun 2026 | Viewed by 59 | Submission Open

Keywords: long-term symptom management; palliative care; awareness; coping strategies; survivorship; caregiver; multidisciplinary care coordination

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

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