Advances in Clinical Treatment of Pancreatic Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 18
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pancreatic duct adenocarcinoma (PDAC) remains among the pancreatic malignancies with the worst outcomes. Survival has been improving, but at a slower rate than other cancers. Multimodal treatment, including chemotherapy, surgical resection and radiotherapy, has been investigated for many years, and actually the role of neoadjuvant chemotherapy is becoming preponderant. Because of the anatomical characteristics of the pancreas, more emphasis in treatment selection has been placed on local extension into major vessels. The poor prognosis of PDAC is in fact influenced by late detection and poor response to existing oncologic treatments. In about one-third of patients, pancreatic cancer has a high propensity for a local spread pattern, surrounding and invading nearby vascular structures. This may be referred to a borderline-resectable (BR-PDAC) or locally advanced PDAC (LA-PDAC), based on the progression of local disease.
Recently, some international guidelines were published focusing on this more aggressive local strategy, even if there is still a veiled pessimism regarding whether surgeons can really counteract the biological aggressiveness of this tumor with the application of an advanced surgical technique. Furthermore, a new dimension is entering the field of pancreatic cancer: the treatment of oligometastatic disease. Both topics can be explored through the protective effects of neoadjuvant regimens.
Others uncommon malignant pancreatic neoplasms are nowadays experiencing changes in their presentation and treatment modality, such as neuroendocrine tumors (NETs). There is ongoing debate regarding how to follow and, more precisely, how to dectect the correct timing to follow and treat cystic pancreatic neoplasms with degenerative potential to avoid local or spread disease.
Based on this, we are excited to invite some excellent authors around the world who can contribute with their research and personal experiences to a Special Issue titled “Advances in Clinical Treatment of Pancreatic Cancers”.
Dr. Alberto Brolese
Guest Editor
Manuscript Submission Information
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Keywords
- pancreatic cancer
- PDAC
- neoadjuvant chemotherapy
- neuroendocrine tumors
- pNET
- pancreatic cystic disease
- IPMN
- pancreatic oligometastases
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